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Clinical Evidence

Peer-Reviewed Clinical Studies

2022

Nair, H. K. R., B. A. Bosque and S. G. Dowling (2022). “Use of an advanced extracellular matrix dressing in the treatment of acute and chronic wounds: a Malaysian case series.” Wounds Asia 5(1): 40 – 46.

Full-text available | View

Al Mousa, R. H., B. A. Bosque and S. G. Dowling (2022). “Use of ovine forestomach matrix in the treatment of facial thermal burns.” Wounds 34(4): e17-21.

Full-text available | View

2021

Bosque, B. A., C. Frampton, A. E. Chaffin, G. A. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2021). “Retrospective real-world comparative effectiveness of ovine forestomach matrix and collagen/ORC in the treatment of diabetic foot ulcers.” Int Wound J 2021 Aug 6 (Epub ahead of print).

Full-text available | View

Boyar, V. (2021). “Association of Systemic or Intravitreal Antivascular Endothelial Growth Factor (Anti-VEGF) and Impaired Wound Healing in Pediatric Patients: Collagen to the Rescue.” J Wound Ostomy Continence Nurs 48(3): 256-261.

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Blevins, M. (2021). “Atypical Ulcerative Necrobiosis Lipoidica Diabeticorum: A Case Study.” Int J Low Extrem Wounds: 1534734621999269.

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2020

Raizman R, Hill R, Woo K. Prospective Multicenter Evaluation of an Advanced Extracellular Matrix for Wound Management [published online ahead of print, 2020 May 27]. Adv Skin Wound Care 33(8): 437-444.

Full-text available | View

2017

Lullove, E. J. (2017). “Use of Ovine-based Collagen Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foam Dressings to Help Improve Clinical Outcomes in Lower Extremity Wounds: A Retrospective Cohort Study.” Wounds 29(4): 107-114.

Full-text available | View

Ferreras, D. T., S. Craig and R. Malcomb (2017). “Use of an Ovine Collagen Dressing with Intact Extracellular Matrix to Improve Wound Closure Times and Reduce Expenditures in a US Military Veteran Hospital Outpatient Wound Center.” Surg Technol Int 30: 61-69.

Full-text available | View

2016

Gonzalez, A. (2016). “Use of Collagen Extracellular Matrix Dressing for the Treatment of a Recurrent Venous Ulcer in a 52-Year-Old Patient.” J Wound Ostomy Continence Nurs 43(3): 310-312.

Abstract only | View

2014

Bohn, G. A. and K. Gass (2014). “Leg ulcer treatment outcomes with new ovine collagen extracellular matrix dressing: a retrospective case series.” Adv Skin Wound Care 27(10): 448-454.

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2013

Simcock, J. W., M. Than, B. R. Ward and B. C. May (2013). “Treatment of ulcerated necrobiosis lipoidica with ovine forestomach matrix.” J Wound Care 22(7): 383-384.

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Simcock, J. and B. C. May (2013). “Ovine forestomach matrix as a substrate for single-stage split-thickness graft reconstruction.” Eplasty 13: e58.

Full-text available | View

Liden, B. A. and B. C. May (2013). “Clinical outcomes following the use of ovine forestomach matrix (endoform dermal template) to treat chronic wounds.” Adv Skin Wound Care 26.

Abstract only | View

Conference Proceedings

2022

Gilleece, D. and A. Sutton (2022). Extracellular matrix technology as an adjunct to prevent limb amputation in the diabetic foot ulcer (DFU) population. NZWCS Conference 2022, 15-17 September Hamilton, New Zealand.

Full-text available | View

Morgan, B. (2022). Advanced ECM technology for the treatment of surgical wounds resulting from a recurrent pressure injury. NZWCS Conference 2022, 15-17 September Hamilton, New Zealand.

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Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2022). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. World Union of Wound Healing Societies, 1-5 March 2022, Abu Dhabi.

Full-text available | View

Al Mousa, R. H., B. A. Bosque and S. G. Dowling (2022). A Case Report: Utilizing Ovine Forestomach Matrix in the Subacute Treatment of Fascial Thermal Burn. World Union of Wound Healing Societies, 1-5 March 2022, Abu Dhabi.

Full-text available | View

Geiger, J. E. J., R. Kaufman, I. Zilberman, N. Zolfaghari, W. Dutch and B. A. Bosque (2022). Continuity of Care: Retrospective Review of Ovine Forestomach Matrix Efficacy Across All Phases of Wound Healing. Symposium on Advanced Wound Care – Spring 2022, April 6-10, 2022, Phoenix, AZ.

Full-text available | View

Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2022). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. American Professional Wound Care Association, Wound Week, 2022 (Feburary 24-27, 2022), Loews Philadelphia Hotel, Philadelphia, PA.

Full-text available | View

Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2022). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. John A. Boswick Burn and Wound Care Symposium January 21-26, 2022, Wailea Beach Resort – Marriott – Wailea – Maui, Hawaii.

Full-text available | View

2021

Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2021). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. Symposium on Advanced Wound Care – Fall, 2021 (October 29-31, 2021), Las Vegas, NV.

Full-text available | View

Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2021). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. DFCon – Diabetic Global Foot Conference, October 21 – 23, 2021. San Franciso, California.

Full-text available | View

2020

Duong, C. H. and J. McGuire (2020). Combination therapy of an bioresorbable synthetic polymer matrix and an ovine collagen dressing for treatment of a recurrent venous leg ulcer: A case study. Symposium on Advanced Wound Care – Fall, 2020 (Nov 4-6), Las Vegas, NV.

Full-text available | View

Melin, M. and C. Zeleya (2020). Chronic wound management with the innovative ovine extracellular matrix technology: a Honduran experience. Symposium on Advanced Wound Care – Spring 2020 Virtual.

Full-text available | View

2019

Raizman, R., R. Hill and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. Wounds Canada – Spring, Halifax, NS, Canada.

Full-text available | View

Hill, R., R. Raizman and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. NSWOCC 38th National Conference, Lac-Leamy, Ottawa, Canada.

Full-text available | View

Stillerman, J. and D. M. Freeman (2019). Using Advanced and Adaptive Technologies for the Management of Wounds – Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foam Dressing. Symposium for Advanced Wound Care – Spring, San Antonio, TX.

Full-text available | View

Zilberman, I. and N. Zolfaghari (2019). The Management of Wounds with Exposed Tendon and Bone using Innovative and Complementary Technologies: Ovine Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foams. Symposium on Advanced Wound Care – Spring, San Antonio, TX.

Full-text available | View

Morrisette, S., R. Casilang and G. Bohn (2019). Extracellular Matrix Technology for Assessing Wound Protease Concentrations Symposium of Advanced Wound Care – Spring, San Antonio, Tx.

Full-text available | View

Zilberman, I. and N. Zolfaghari (2019). The management of wounds with exposed tendon and bone with innovative and complementary technologies: ovine extracellular matrix and gentian violet/methylene blue antibacterial foams. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Woo, K., R. Raizman and R. Hill (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Hill, R., R. Raizman and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. Wounds Canada – Fall, Niagara Falls, Ontario, Canada.

Full-text available | View

Hill, R., R. Raizman and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. European Pressure Ulcer Advisory Panel & Société Française de l’Escarre Joint Annual Meeting 2019, Lyon, France

Full-text available | View

2018

Stillerman, J. (2018). Case Series Using Ovine Extracellular Matrix for the Correction of Stalled Wounds Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Silverman, A. and G. Valentine (2018). Use of Ovine Extracellular Matrix in Post-Surgical Wounds: A Case Series. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Morrisette, S., E. Hicks and R. Casilang (2018). Achieving Improved Wound Healing Time and Costs Savings in the Outpatient Wound Care Setting by Utilizing an Extracellular Matrix. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Andersen, C., D. Green, J. Santucci and E. Phillips (2018). Improved Venous Leg Ulcer Outcomes Using a Combination of Ovine Extracellular Matrix and Gentian Violet/Methylene Blue Transfer Antibacterial Foam. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Tickner, A., C. Klinghard and K. Lussier (2018). The Use of Ovine Collagen Extracellular Matrix Dressing in the Effective Treatment of Wounds for Fast Closure and Treatment of Nerve Pain. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

Gatan Mendoza, J., J. Landi and R. Rock (2018). The concurrent Use of Ovine Collagen Extracellular Matrix Dressing with Negatvie Pressure Wound Therapy on Three Acute Surgical Wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

Full-text available | View

Mier, Y. (2018). Case Series of using collagen dressing in stalled wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

Full-text available | View

Lindberg, G. and M. Diss (2018). Complete Wound Closure in Partial Thickness Burns with the Use of Collagen Extracellular Matrix Dressings and Antibacterial Foams. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

Full-text available | View

Jerome, D. and J. Clancy (2018). Incorporating advanced wound care to help restore skin health in three patients with peristomal skin complications. Wound Ostomy and Continence Nurse Conference, St. Louis, MO.

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Fleck, K. A., T. Reyes and H. C. Wishall (2018). Effect of Ovine-Based Collagen Extracellular Matrix Dressings on Outcomes in an Outpatient Wound Care Center. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

Full-text available | View

Aballay, A. and E. Tolchin (2018). Results of an ovine extracellular matrix dressing in the management of a variety of burns and wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

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2017

Silverman, A. (2017). Use of an Ovine Collagen with an Intact Extracellular Matrix (CECM) and negative pressure wound therapy (NPWT) as part of the wound management plan following limb salvage surgical intervention in high risk diabetic foot ulcers. Symposium on Advanced Wound Care – Spring, San Diego, CA.

Full-text available | View

McIlrath, P. and J. T. Wattlers (2017). The Use of Ovine Collagen Extracellular Matrix and Gentian Violet and Methylene Blue Antibacterial Foam Dressings in the Effective Treatment of Wounds with Exposed Tendon and Bone in the High Risk Diabetic Foot. Society for Advanced Wound Care – Spring, San Diego, CA.

Full-text available | View

2016

Zilberman, I. and N. Zolfaghari (2016). Innovative solutions in the management of wounds with exposed tendons utilizing ovine collagen extracellular matrix and gentian violet and methylene blue antibacterial foams. Symposium for Advanced Wound Care – Spring, Atlanta, GA.

Full-text available | View

Vidovic, G. and P. Sykes (2016). The use of an ovine collagen extracellular matrix dressing in conjunction with negative pressure wound therapy in the management of chronic diabetic foot ulcers. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Roith, J. (2016). Managing Diabetic Foot Ulcers Using a Three Pronged Approach: V.I.P. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Petrocelli, M. (2016). Managing Difficult Wounds Secondary to Charcot Deformity with a Novel Total Contact Cast System. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Petrocelli, M. Ostler, M. Liden, B. (2016). Edema reduction with a Novel Total Contact Cast System containing a Mild Compression Sock. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Gonzalez, A. (2016). Use of Collagen Extracellular Matrix Dressing for the Treatment of a Recurrent Venous Ulcer in a 52-Year-Old Patient. Symposium on Advanced Wound Care – Spring, Atlanta, GA.

Full-text available | View

Ferreras, D. T., S. Craig and R. Malcomb (2016). Utilization of an ovine collagen dressing with an intact extracellular matrix (CECM) within a dual-protocol algorithm to improve wound closure times and reduce expenditures in a VA Hospital. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Edwards, K., White S. (2016). Use of gentian violet and methylene blue antibacterial foam dressings on various wound types in the acute care setting. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Desvigne, M. N. (2016). Preparing a wound bed before application of cellular tissue based products using an Ovine collagen (CECM) dressing with an intact extracellular matrix. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

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Bohn, G. and S. Champion (2016). Improved Healing of Stage 3 Pressure Ulcers Using Extracellular Matrix Collagen Dressing. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

2015

Weir, D., D. Tedesco and G. Schultz (2015). Enhanced Clinical Effects of Combining Recombinant PDGF with Collagen Dressings in Difficult to Heal Chronic Wounds. Symposium for Advanced Wound Care – Spring, New Orleans, LA.

Full-text available | View

Roith, J. and T. Neill (2015). Treating Diabetic Foot Ulcer Patients with an Ovine Collagen Extra Cellular Matrix Prior to cellular Tissue Products. Annual High Risk Diabetic Foot Conference, Phoenix, AZ.

Full-text available | View

Pierce, B., J. Galitz, L. Hayes and M. Regan (2015). Wound Management and Estimated Cost Associated with Dermal Templates Containing 10% Extracellular Matrix Components and 90% Intact Collagen. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

McGuire, J., N. Mahmudova and W. Lee (2015). Using becaplermin and ovine dermal template (ODT) dressing to heal chronic diabetic foot ulcers. A case series. American Podiatric Medical Association 2015 Annual Scientific Meeting (The National), Orlando, FL.

Full-text available | View

Desvigne, M. N. (2015). Ovine collagen extracellular matrix (CECM) Dressing Assisted Closure: For the Acute Wound, Following Mohs Surgical Excision. Clinical Symposium on Advances in Skin & Wound Care. New Orleans, LA.

Full-text available | View

Champion, S. and G. Bohn (2015). Dressing Appearance at Change Can Give Insight into Dressing Effectiveness in the Wound. Symposium on Advances in Skin & Wound Care – Spring, New Orleans, LA.

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2014

Zilberman, I. and N. Zolfaghari (2014). Use of ovine collagen extracellular matrix (CECM) dressing and gentian violet and methylene blue (GV/MB) antimicrobial foam dressing in the management of diabetic foot ulcers. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Lullove (2014). Pilot series of recalcitrant lower extremity wounds managed with an ovine collagen extracellular matrix (CECM) and gentian violet/methylene blue (GV/MB) antibacterial foam dressings. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Blaszcyk, J. and A. McIntosh (2014). The effectiveness of an ovine collagen extracellular matrix dressing for chronic non-healing wounds. Symposium on Advanced Wound Care – Spring, Denver, CO.

Full-text available | View

2013

Wright, K., D. Hastings, W. Dukes and K. Gorgui (2013). Innovative Dressing Option: Use of a collagen dermal template with extracellular matrix (ECM)* in the management of lower extremity wounds. Clinical Symposium on Advances in Skin & Wound Care, Orlando, FL.

Full-text available | View

Pompeo, M., K. Neeley and L. Garner (2013). Utilizing a collagen dermal template in various wound etiologies yielded positive results in an outpatient wound care center. Symposium on Advanced Wound Care – Spring, Denver, CO.

Full-text available | View

Miller, S. D., K. Trotter, B. Hong, R. Lenz, D. Nagesh, H. K. Park and M. Garoufalis (2013). An Approach to Treating Neuropathic Pedal Ulcerations with Ovine Collagen Extracellular Matrix (CECM). Symposium on Advanced Wound Care – Spring, Denver, CO.

Full-text available | View

Lullove, E. (2013). Use of a collagen dermal template with extracellular matrix (ECM) to treat complex lower extremity wounds. Clinical Symposium on Advances in Skin & Wound Care, Orlando, FL.

Full-text available | View

Curran, M., C. Rodriquez, O. J. Altschul, A. Fragen and F. Ercoll (2013). The Use of collagen dermal template with an ECM in various wounds in acute care and outpatient wound care settings. Symposium on Advanced Wound Care – Spring, Denver, CO

Full-text available | View

2011

Liden, B., B. R. Ward and B. C. H. May (2011). Early Clinical Findings from the Use of Ovine Forestomach Matrix to Treat Recalcirant Wounds. Symposium on Advanced Wound Care – Spring, Dallas, Tx.

Full-text available | View

Clinical Consensus Papers

2019

Bohn, G. A. (2019). “Endoform: A Simple Tool to Assess Wound Proteases.” Wound Management and Prevention 65(3): 18-20.

Full-text available | View

Casilang, R. and S. Morrisette (2019). “Utilizing Endoform as a Surrogate Marker of Wound Protease Levels in Chronic Wounds.” Wound Management and Prevention 65(5): 8-10.

Full-text available | View

S. Morrisette (2019). “Using Endoform as a Protease Indicator to Standardize Wound Management.” Wound Management and Prevention 65(8): 8-10.

Full-text available | View

Bohn, G. (2019). “Complex Problem, Simple Solution: Using Endoform to Provide a Functional Extracellular Matrix in Chronic Wounds.” Wound Management and Prevention 65(10): 8-10.

Full-text available | View

Boyar, V. (2019). “Collagen: providing a key to the wound healing kingdom.” Wound Management and Prevention 65(8): 12-14.

Full-text available | View

2018

Gonzalez, A. (2018). “Managing Pressure Injuries in Home Health Care.” Ostomy and Wound Management 64(4): 12-14.

Abstract only | View

Edwards, K. (2018). “Collaborating with WOC Nurses to Optimize Patient Progress.” Ostomy and Wound Management May 2018: 10-12.

Abstract only | View

2017

Ferreras, D. T. (2017). “Wound Bed Preparation: Is It Time to Up Your Game?” Ostomy and Wound Management 63(12): 10-11.

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Bohn, G. A., G. S. Schultz, B. A. Liden, M. N. Desvigne, E. J. Lullove, I. Zilberman, M. B. Regan, M. Ostler, K. Edwards, G. M. Arvanitis and J. F. Hartman (2017). “Proactive and Early Aggressive Wound Management: A Shift in Strategy Developed by a Consensus Panel Examining the Current Science, Prevention, and Management of Acute and Chronic Wounds.” Wounds 29(11): S37-S42.

Full-text available | View

2016

Bohn, G., B. Liden, G. Schultz, Q. Yang and D. J. Gibson (2016). “Ovine-Based Collagen Matrix Dressing: Next-Generation Collagen Dressing for Wound Care.” Adv Wound Care (New Rochelle) 5(1): 1-10.

Full-text available | View

2014

Sibbald, R. G., L. G. Ovington, E. A. Ayello, L. Goodman and J. A. Elliott (2014). “Wound bed preparation 2014 update: management of critical colonization with a gentian violet and methylene blue absorbent antibacterial dressing and elevated levels of matrix metalloproteases with an ovine collagen extracellular matrix dressing.” Adv Skin Wound Care 27(3 Suppl 1): 1-6.

Abstract only | View

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