Overview

Overview

Myriad Matrix™ is an engineered extracellular matrix (ECM) for soft tissue repair, reinforcement and complex wounds. Myriad Matrix™ has been specifically designed to help maximize tissue repair while providing versatility and adaptability across a wide range of surgical applications.

Myriad Matrix™ is designed to be easily customizable for a wide range of anatomical sites and surgical needs and can be used in both implantation and dermal repair.

  • Myriad Matrix™ is strong, soft, drapable, and conforming
  • Myriad Matrix™ rehydrates quickly and is easy to cut, suture or staple
  • Myriad Matrix™ helps to achieve surgical mastery in routine and challenging repair and reinforcement procedures

How It Works

How It Works

Myriad Matrix™ devices contain the natural porous structure of AROA ECM™, engineered with interstitial perforations to enable cell infiltration to facilitate rapid healing.

Fast absorption of blood & cells accelerates host cell infiltration

The rapid absorption of blood and blood components forms a reservoir of biologically important cells and cell components to help kick-start the tissue repair process.(1-4) Fibroblast, endothelial and immune cells infiltrate the entire matrix, build new tissue and over time Myriad Matrix™ is completely remodeled by the patient’s own tissue.(3, 4)

Delivers biology known to be important in healing

Myriad Matrix™ retains the authentic structure and complexity of natural tissue ECM and provides biological cues to aid the repair process.(5) Myriad Matrix™ contains more than 150 ECM proteins, including collagen and other secondary molecules that exist in tissue and aid the healing process.(6)

Contains residual vascular channels

Angioconduction is the structural effect of vascular channels on endothelial cells to support blood vessel development. Myriad Matrix™ promotes angioconduction via the residual vascular channels within the Aroa ECM™ source biomaterial, helping to facilitate the rapid establishment of a dense capillary network.(7, 8)

1.  G. A. Bohn and A. E. Chaffin: Extracellular matrix graft for reconstruction over exposed structures: a pilot case series. J Wound Care, 29(12), 742-749 (2020) doi:10.12968/jowc.2020.29.12.742 2. A. E. Chaffin and M. C. Buckley: Extracellular matrix graft for the surgical management of Hurley stage III hidradenitis suppurativa: a pilot case series. J Wound Care, 29(11), 624-630 (2020) doi:10.12968/jowc.2020.29.11.624 3. S. M. Irvine, J. Cayzer, E. M. Todd, S. Lun, E. W. Floden, L. Negron, J. N. Fisher, S. G. Dempsey, A. Alexander, M. C. Hill, A. O’Rouke, S. P. Gunningham, C. Knight, P. F. Davis, B. R. Ward and B. C. H. May: Quantification of in vitro and in vivo angiogenesis stimulated by ovine forestomach matrix biomaterial. Biomaterials, 32(27), 6351-61 (2011) doi:l10.1016/j.biomaterials.2011.05.040 4. N. Overbeck, G. M. Nagvajara, S. Ferzoco, B. C. H. May, A. Beierschmitt and S. Qi: In-vivo evaluation of a reinforced ovine biologic: a comparative study to available hernia mesh repair materials. Hernia, 10.1007/s10029-019-02119-z (2020) 5. S. Lun, S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. May: A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 31(16), 4517-29 (2010) doi:10.1016/j.biomaterials.2010.02.025 6. S. G. Dempsey, C. H. Miller, R. C. Hill, K. C. Hansen and B. C. H. May: Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix. J Proteome Res, 18(4), 1657-1668 (2019) doi:10.1021/acs.jproteome.8b00908 7. Data on file  8. N. S. Greaves, S. A. Lqbal, J. Morris, B. Benatar, T. Alonso-Rasgado, M. Baguneid and A. Bayat: Acute cutaneous wounds treated with human decellularised dermis show enhanced angiogenesis during healing. PLoS One, 10(1), e0113209 (2015) doi:10.1371/journal.pone.0113209

Formats

Formats

Indications

Indications

Myriad Matrix™ is indicated for implantation to reinforce soft tissue where weakness exists in patients requiring soft tissue repair or reinforcement in plastic and reconstructive surgery, or for management of the following wounds:

  • Partial and full thickness wounds
  • Pressure ulcers
  • Venous ulcers
  • Diabetic ulcers
  • Chronic vascular ulcers
  • Tunneled/ undermined wounds
  • Surgical wounds (donor sites, grafts, post Moh’s surgery, post laser surgery, podiatric, wound dehiscence)
  • Trauma wounds (abrasions, lacerations, second-degree burns, and skin tears)
  • Draining wounds
Clinical Evidence

Clinical Evidence

Peer-Reviewed Clinical Studies

2021

Chaffin, A. E., S. G. Dowling, M. S. Kosyk and B. A. Bosque (2021). “Surgical reconstruction of pilonidal sinus disease with concomitant extracellular matrix graft placement: a case series.” J Wound Care 30(Sup7): S28-S34.

Full-text available | View

2020

Desvigne, M. N., K. Bauer, K. Holifield, K. Day, D. Gilmore and A. L. Wardman (2020). “Case Report: Surgical Closure of Chronic Soft Tissue Defects Using Extracellular Matrix Graft Augmented Tissue Flaps.” Frontiers in Surgery 7(173).

Full-text available | View

Chaffin, A. E. and M. C. Buckley (2020). “Extracellular matrix graft for the surgical management of Hurley stage III hidradenitis suppurativa: a pilot case series.” J Wound Care 29(11): 624-630.

Full-text available | View

Bohn, G. A. (2020). “Using Ovine Extracellular Matrix in Difficult to Close Excisions of Common Skin Cancer: an Evolving New Technique.” Surg Technol Int 37: 49-53.

Abstract only | View

Bohn, G. A. and A. E. Chaffin (2020). “Extracellular matrix graft for reconstruction over exposed structures: a pilot case series.” J Wound Care 29(12): 742-749.

Full-text available | View

2013

Simcock, J., & May, B. C. (2013). Ovine forestomach matrix as a substrate for single-stage split-thickness graft reconstruction. Eplasty, 13, e58.

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Conference Proceedings

2023

Desrosiers III, A. (2022). Postsurgical Pyoderma Gangrenosum in Bilateral Breast Reduction Surgery. Innovations in Wound Healing, Dec 04 – 07, 2022. Florida, USA.

Chaffin, A. E., M. Melin and L. Mohan (2022). Novel treatment algorithm of Pyoderma Gangrenosum with Hypochlorous acid and Ovine Forestomach Matrix; Can the dogma of pathergy be altered? Innovations in Wound Healing, Dec 04 – 07, 2022. Florida, USA.

2022

LaLama, A. J. (2022). Ovine Forestomach Matrix in the Surgical Management of Scleroderma Skin Ulcer. Symposium for Advanced Wound Care – Fall, November 2-5, Las Vegas, NV.

Full-text available | View

Canfield, A. and R. Kemp (2022). Ovine Forestomach Matrix in the Management of a Complicated Abdominal Surgical Dehiscence. Symposium for Advanced Wound Care – Fall, November 2-5, Las Vegas, NV.

Full-text available | View

Chaffin, A. E. (2022). Full Thickness Wound Reconstruction After Wide Excision of Recurrent Plantar Fibromatosis. Symposium for Advanced Wound Care – Fall, November 2-5, Las Vegas, NV.Symposium for Advanced Wound Care – Fall, November 2-5, Las Vegas, NV.

Full-text available | View

Taarea, R., J. J. Donahue and C. Castater (2022). Ovine Forestomach Matrix in the Surgical Management of Complex and Contaminated Soft Tissue Trauma. Symposium for Advanced Wound Care – Fall, November 2-5, Las Vegas, NV.

Full-text available | View

Howie, Q., J. Longobardi, M. M. Melin, R. Kaufman, J. J. E. Geiger, I. Zilberman, J. W. Dutch, J. Skurka, B. A. Bosque and S. G. Dowling (2022). Clinical Effectiveness of Ovine Forestomach Matrix Graft in Complex Lower Limb Reconstruction and Limb Salvage. Diabetic Global Foot Conference, September 29th-October 1st, Los Angeles, CA.

Full-text available | View

Hsu, A. T.-W., K. Schlidt, C. R. D’Adamo, B. A. Bosque, S. G. Dowling and J. H. Wolf (2022). Successful outcomes in anal fistula treatment using ovine forestomach matrix implant technique. ASCRS Annual Scientific Meeting, April 30 – May 4, Tampa, FL.

Full-text available | View

Kokal, W. and P. Price (2022). A Case Report of the Treatment of Pemphigus Vulgaris Utilizing an Extracellular Matrix Graft (Oral Presentation). John A. Boswick Burn and Wound Care Symposium January 21-26, 2022, Wailea Beach Resort – Marriott – Wailea – Maui, Hawaii.

Full-text available | View

Melin, M. (2022). Clinical Effectiveness of Ovine Forestomach Matrix Graft in Complex Lower Limb Reconstruction and Limb Salvage (Oral Presentation). John A. Boswick Burn and Wound Care Symposium January 21-26, 2022, Wailea Beach Resort – Marriott – Wailea – Maui, Hawaii.

Chaffin, A. E. (2022). Morselized Extracellular Matrix Graft to Improve Split Thickness Skin Graft Outcomes: A Retrospective Case Series (Oral Presentation). John A. Boswick Burn and Wound Care Symposium January 21-26, 2022, Wailea Beach Resort – Marriott – Wailea – Maui, Hawaii.

Chaffin, A. E. (2022). A surgical technique for flap reconstruction of pilonidal sinus using extracellular matrix graft (oral presentation). World Union of Wound Healing Societies, 1-5 March 2022, Abu Dhabi.

Melin, M., R. Kaufman, J. E. J. Geiger and B. A. Bosque (2022). Ovine Forestomach Matrix in the Surgical Management of Complex Lower Extremity Soft Tissue Defects : A Retrospective Multi-Center Case Series. American Professional Wound Care Association, Wound Week, 2022 (February 24-27, 2022) Loews Philadelphia Hotel, Philadelphia, PA.

Full-text available | View

Geiger, J. E. J., R. Kaufman, I. Zilberman, N. Zolfaghari, W. Dutch and B. A. Bosque (2022). Continuity of Care: Retrospective Review of Ovine Forestomach Matrix Efficacy Across All Phases of Wound Healing. Symposium on Advanced Wound Care – Spring 2022, April 6-10, 2022, Phoenix, AZ.

Full-text available | View

Chaffin, A. E., J. Christopher and B. Salah (2022). A retrospective review of soft tissue reconstruction in volumetric soft tissue defects. Symposium on Advanced Wound Care – Spring 2022, April 6-10, 2022 Phoenix, AZ.

Full-text available | View

Register, A. (2022). A retrospective review of an extracellular matrix used to treat complex chronic wounds. Symposium on Advanced Wound Care – Spring 2022, April 6-10, 2022, Phoenix, AZ.

Full-text available | View

Melin, M. M., R. Kaufman, J. E. J. Geiger, I. Zilberman, N. Zolfaghari, H. Que, J. Longoardi, W. Dutch, J. Skurka, B. A. Bosque and S. G. Dowling (2022). Clinical Effectiveness of Ovine Forestomach Matrix Graft in Complex Lower Limb Reconstruction and Limb Salvage. Symposium on Advanced Wound Care – Spring, April 6-10, 2022, Phoenix, AZ.

Full-text available | View

2021

Chaffin, A. E. and J. Christopher (2021). A retrospective review of the early experience with a morselized extracellular matrix. Symposium on Advanced Wound Care – Fall, 2021 (October 29-31), Las Vegas, NV.

Full-text available | View

Holloway, B. (2021). Minimally Invasive Closure for Recurrent Pilonidal Sinus Using Extracellular Matrix Graft: A Case Report. Symposium on Advanced Wound Care – Fall, 2021 (October 29-31), Las Vegas, NV.

Full-text available | View

Geiger, A. J., B. A. Bosque and R. Kaufman (2021). Clinical Effectiveness of Ovine Forestomach Matrix for Coverage of Exposed Vital Structures in Complex Diabetic Foot Ulcer Reconstructions. DFCon – Diabetic Global Foot Conference, October 21 – 23, 2021. San Francisco, California.

Full-text available | View

Chaffin, A. E. (2021). Flap Reconstruction of Pilonidal Sinus Using Extracellular Matrix Graft: A Pilot Case Series. Symposium on Advanced Wound Care (SAWC) – Spring, Virtual.

Full-text available | View

Chaffin, A. E. (2021). A Surgical Technique for Flap Reconstruction of Pilonidal Sinus Using Extracellular Matrix Graft (Oral Presentation). 44th Annual John A. Boswick Burn & Wound Symposium, Maui, HI.

Full-text available | View

2020

Wahab, N., Lapucha, M., and C. Chauhan (2020). Ovine Forestomach Matrix is Efficacious in the Closure of Significant Post Surgical Undermining. Symposium on Advanced Wound Care – Spring, Virtual Conference.

Full-text available | View

Chaffin, A. E., and M. Buckley (2020). Clinical Evaluation of an Extracellular Matrix Graft for the Surgical Management of Hurley Grade III Hidradenitis Suppurativa. Symposium of Advanced Wound Care, Virtual Conference.

Full-text available | View

Chaffin, A. E. and M.-C. Buckley (2020). Surgical Management of Hurley Stage III Hidradenitis Suppurativa Using ECM Graft. Symposium on Hidradenitis Suppurativa Advances, 5th Annual SHSA, October 9-11 2020, Virtual.

Full-text available | View

Geiger, J. E. J. and J. Skwarczyk (2020). Extracellular matrix-based regeneration over exposed bone and tendon: A prospective case series. DFCon 20 Conference, Oct 9-10 2020, Virtual.

Full-text available | View

Chaffin, A. E. (2020). Pilonidal Cystectomy Using Extracellular Matrix Graft. Symposium on Advanced Wound Care – Fall, November 4-6 2020, Virtual.

Full-text available | View

2019

Chaffin, A. E., A. M. Aballay, G. A. Bohn, P. M. Glat, M. N. Desvigne and B. C. H. May (2019). Multi-Centre Clinical Evaluation of a Cell Conductive Extracellular Matrix Surgical Mesh in Plastics and Reconstructive Surgery – A Case Series. 41st Annual Boswick Burn & Wound Symposium, Wailea Beach, Maui, HI.

Full-text available | View

Chaffin, A. E., A. M. Aballay, G. A. Bohn, P. M. Glat, M. N. Desvigne and B. C. May (2019). Multi-Centre Clinical Evaluation of a Cell Conductive Extracellular Matrix Surgical Mesh in Plastics and Reconstructive Surgery – A Case Series. SESPRS 62nd Annual Scientific Meeting, Naples, Florida.

Full-text available | View

Ferreras, D. T. and R. L. Crump (2019). Use of a High-Density ECM for the Management of Deep Diabetic Foot Ulcers: A Case Series. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Chaffin, A. E. and G. Bohn (2019). Clinical Evaluation of an Extracellular Matrix Surgical Graft for Reconstructive Surgery over Exposed Bone or Tendon. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Product Resources

Product Resources

Video Library

Myriad™ – Post Surgical Dehiscence

Watch Video

Myriad Matrix™ Use in the Treatment of Pemphigus Vulgaris

Watch Video

Myriad Matrix™ Reconstruction of Hidradenitis Suppurativa

Watch Video

Myriad Matrix™ Wound Dehiscence

Watch Video

Myriad Matrix™ Scalp Reconstruction

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A Surgical Technique for Flap Reconstruction of Pilonidal Sinus Using Extracellular Matrix Graft

Watch Video

Myriad Matrix™ in Forearm Reconstruction & Z-Plasty Revision

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Aroa Biosurgery – Unlocking regenerative healing for everybody

Watch Video

Downloadable Documents
Myriad Matrix™ Coverage and Coding Guide

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Myriad Matrix™ Application Notes and Clinical Evidence Guide

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Myriad Matrix™ Brochure

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Myriad Matrix™ Hidradenitis Suppurativa Clinical Resource

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Myriad Matrix™ IFU

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Myriad™ Post-Op Care Guide

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Myriad Matrix™ Pilonidal Sinus Disease Clinical Resource

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