Endoform™
Overview
Endoform™ Antimicrobial Restorative Bioscaffold and Endoform™ Natural Restorative Bioscaffold are unique extracellular matrix (ECM) products for the management of acute and chronic wounds. Endoform™ products support all phases of wound healing and are appropriate for use early in wound management to restore protease balance and advance healing to the proliferative phase.(1)
Overview
Endoform™ Natural Restorative Bioscaffold is a unique extracellular matrix (ECM) product for the management of acute and chronic wounds. Endoform™ products support all phases of wound healing and are appropriate for use early in wound management to restore protease balance and advance healing to the proliferative phase.(1)
Endoform™ products:
- Provide a natural porous ECM bioscaffold for rapid cell infiltration(2)
- Contain more than 150 ECM proteins known to be important in wound healing(3)
- Contain residual vascular channels to support the establishment of new vasculature(4)
- Can indicate the presence or absence of proteases and help restore protease balance and guide re-application(5)
- Can be used by any wound care provider from day 1(1)
Endoform™ Antimicrobial Restorative Bioscaffold contains 0.3% ionic silver, appropriate for use in early acute and chronic wound management where there is an elevated risk of infection.
- Provides broad spectrum antimicrobial activity for up to 7 days*(6)
- Prevents biofilm formation(6)
- Is non-cytotoxic to dermal cells(6)
Endoform™ products:
- Provide a natural porous ECM bioscaffold for rapid cell infiltration(2)
- Contain more than 150 ECM proteins known to be important in wound healing(3)
- Contain residual vascular channels to support the establishment of new vasculature(4)
- Can indicate the presence or absence of proteases and help restore protease balance and guide re-application(5)
- Can be used by any wound care provider from day 1(1)
*Endoform™ Antimicrobial contains 0.3% ionic silver to protect the dressing from microbial colonization
Ionic silver has been included in Endoform™ Antimicrobial to protect the device from microbial contamination. Reduction in colonization or microbial growth on the device has not been shown to correlate with a reduction in infections in patients. Clinical studies to evaluate reduction in infection have not been performed.
1. Ferreras, D. T., S. et al. Surg Technol Int 30: 61-69. 2. G. A. Bohn, G. S. et al. Wounds, 29(11), S37-S42 (2017). 3. Bosque, B. A. et al. Int Wound J 2021 Aug 6 (Epub ahead of print). 4. Negron et al. Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase.
Please contact your local sales representative or distributer to see what products are available to you.
1. G. A. Bohn, G. S. Schultz, B. A. Liden, M. N. Desvigne, E. J. Lullove, I. Zilberman, M. B. Regan, M. Ostler, K. Edwards, G. M. Arvanitis and J. F. Hartman: Proactive and Early Aggressive Wound Management: A Shift in Strategy Developed by a Consensus Panel Examining the Current Science, Prevention, and Management of Acute and Chronic Wounds. Wounds, 29(11), S37-S42 (2017). 2. S. Lun, S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. May: A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 31(16), 4517-29 (2010) doi:10.1016/j.biomaterials.2010.02.025. 3. S. G. Dempsey, C. H. Miller, R. C. Hill, K. C. Hansen and B. C. H. May: Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix. J Proteome Res, 18(4), 1657-1668 (2019) doi:10.1021/acs.jproteome.8b00908. 4. Smith MJ, Dempsey SG, Veale RW, et al. Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair. Journal of Biomaterials Applications. 2022;36(6):996-1010. doi:10.1177/08853282211045770. 5. G. A. Bohn: Endoform: A Simple Tool to Assess Wound Proteases. Wound Management and Prevention, 65(3), 18-20 (2019). 6. T. Karnik, S. G. Dempsey, M. J. Jerram, A. Nagarajan, R. Rajam, B. C. H. May and C. H. Miller: Ionic silver functionalized ovine forestomach matrix – a non-cytotoxic antimicrobial biomaterial for tissue regeneration applications. Biomater Res, 23, 6 (2019) doi:10.1186/s40824-019-0155-0
How It Works
Endoform™ Natural Restorative Bioscaffold products work in all phases of healing to stabilize, correct, build and organize tissue.
Endoform™ products are made from AROA ECM™ technology and contain more than 150 extracellular matrix (ECM) proteins that enable it to interact with patient’s cells throughout all phases of healing.(1, 2) Endoform™ products are 85% collagen and 15% important secondary molecules, including structural and adhesion proteins, and glycosaminoglycans (GAGs).(1) Endoform™ products only contain components found in tissue extracellular matrix.
During the inflammatory phase, chronic wounds are characterized by elevated wound proteases that limit healing by digesting important dermal proteins.(3) Endoform™ products can help indicate the presence or absence of proteases and restores protease balance.(4, 5) If Endoform™ products are not visible in the wound bed at the time of reapplication, this can indicate elevated wound protease activity. However, if Endoform™ is visible, this can indicate that protease balance has been restored.
Endoform™ products also contain residual vascular channels that facilitate the rapid establishment of a dense capillary network by supporting migrating endothelial cells to establish new vasculature and a robust blood supply to help build new tissue.(6) This process is termed angioconduction.
Endoform™ Antimicrobial and Endoform™ Natural Restorative Bioscaffold products work in all phases of healing to stabilize, correct, build and organize tissue.
Endoform™ products are made from AROA ECM™ technology and contain more than 150 extracellular matrix (ECM) proteins that enable it to interact with patient’s cells throughout all phases of healing.(1, 2) Endoform™ products are 85% collagen and 15% important secondary molecules, including structural and adhesion proteins, and glycosaminoglycans (GAGs).(1) Endoform™ products only contain components found in tissue extracellular matrix.
During the inflammatory phase, chronic wounds are characterized by elevated wound proteases that limit healing by digesting important dermal proteins.(3) Endoform™ products can help indicate the presence or absence of proteases and restores protease balance.(4, 5) If Endoform™ products are not visible in the wound bed at the time of reapplication, this can indicate elevated wound protease activity. However, if Endoform™ is visible, this can indicate that protease balance has been restored.
Endoform™ products also contain residual vascular channels that facilitate the rapid establishment of a dense capillary network by supporting migrating endothelial cells to establish new vasculature and a robust blood supply to help build new tissue.(6) This process is termed angioconduction.
1. S. Lun, S.M. Irvine, K.D. Johnson, N.J. Fisher, E.W. Floden, L. Negron, S.G. Dempsey, R.J. McLaughlin, M. Vasudevamurthy, B.R. Ward, B.C. May, A functional extracellular matrix biomaterial derived from ovine forestomach, Biomaterials 31(16) (2010) 4517-29. 2. S.G. Dempsey, C.H. Miller, R.C. Hill, K.C. Hansen, B.C.H. May, Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix, J Proteome Res 18(4) (2019) 1657-1668. 3. R. Lobmann, A. Ambrosch, G. Schultz, K. Waldmann, S. Schiweck, H. Lehnert, Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients, Diabetologia 45(7) (2002) 1011-6. 4. G.A. Bohn, Endoform: A Simple Tool to Assess Wound Proteases, Wound Management and Prevention 65(3) (2019) 18-20. 5. L. Negron, S. Lun, B.C.H. May, Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase, Int Wound J 11(4) (2012) 392-397. 6. Smith MJ, Dempsey SG, Veale RW, et al. Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair. Journal of Biomaterials Applications. 2022;36(6):996-1010. doi:10.1177/08853282211045770
Indications
Endoform™ Antimicrobial Restorative Bioscaffold and Endoform™ Natural Restorative Bioscaffold products are indicated for the management of acute and chronic wounds including:
- Partial and full-thickness wounds
- Pressure ulcers
- Venous ulcers
- Diabetic ulcers
- Chronic vascular ulcers
- Tunneled/undermined wounds
- Surgical wounds (donor sites, grafts, post Moh’s surgery, post laser surgery, podiatric, wound dehiscence)
- Traumatic wounds (abrasions, lacerations, second-degree burns, and skin tears)
- Draining wounds
Indications
Endoform™ Natural Restorative Bioscaffold products are indicated for the management of acute and chronic wounds including:
- Partial and full-thickness wounds
- Pressure ulcers
- Venous ulcers
- Diabetic ulcers
- Chronic vascular ulcers
- Tunneled/undermined wounds
- Surgical wounds (donor sites, grafts, post Moh’s surgery, post laser surgery, podiatric, wound dehiscence)
- Traumatic wounds (abrasions, lacerations, second-degree burns, and skin tears)
- Draining wounds
Clinical Evidence
ClearConference Proceedings
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- Aburn, R., B. C. H. May, C. Frampton, A. E. Chaffin, G. Bohn and M. Melin (2024). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Venous Leg Ulcers: An Interim Analysis. Innovations in Wound Healing, Dec 3-6, Islamorada, FL.
- Aburn, R. (2024). The Ultimate Patient Outcome Showdown: Live Wound Care “Boxing” Championships – Surgeon vs Nurse Finals (Oral Presentation). 34th Conference of the European Wound Management Association (EWMA), May 1-3, London, UK.
- Lee, C. Y. (2024). The Application of the Ovine Forestomach Matrix with Negative Pressure Wound Therapy in the Management of Complex Volumetric Soft Tissue Defects. 34th Conference of the European Wound Management Association (EWMA), May 1-3, London, UK.
- Bosque, B. A., R. W. F. Veale, T. Kollmetz, N. Taghavi, C. G. Duston-Fursman, M. T. Beeson, D. Asefi, H. D. Chittock, A. S. Vikranth, S. G. Dowling, S. G. Dempsey, H. J. Rose, I. T. T. Mason and B. C. H. May (2023). Influence of advanced wound matrices on observed vacuum pressure during simulated negative pressure wound therapy. Wild on Wounds (WOW), Sep 13-16 Hollywood, FL.
- Scarpa, C. (2023). The Ovine Extracellular Matrix in Acute and Chronic Wounds: Our Preliminary Experience. European Wound Management Association, 03-05 May, 2023. Milan, Italy.
- Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. May (2023). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. Nurses Specialized in Wound, Ostomy and Continence Canada, May 03-07, 2023. Ottawa, Ontario, Canada. Full-text available | View
- Blasina, M. (2023). Use of ECM Scaffold Derived From Ovine Forestomach: An Italian Experience in Outpatient and Inpatient Settings. European Wound Management Association, 03-05 May, 2023. Milan, Italy.
- Bosque, B. A., C. Frampton, A. E. Chaffin, G. A. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2023). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. European Wound Management Association, 03-05 May, 2023. Milan, Italy. Full-text available | View
- Morgan, B. (2022). Advanced ECM technology for the treatment of surgical wounds resulting from a recurrent pressure injury. NZWCS Conference 2022, 15-17 September Hamilton, New Zealand. Full-text available | View
- Geiger, J. E. J., R. Kaufman, I. Zilberman, N. Zolfaghari, W. Dutch and B. A. Bosque (2022). Continuity of Care: Retrospective Review of Ovine Forestomach Matrix Efficacy Across All Phases of Wound Healing. Symposium on Advanced Wound Care – Spring 2022, April 6-10, 2022, Phoenix, AZ. Full-text available | View
- Gilleece, D. and A. Sutton (2022). Extracellular matrix technology as an adjunct to prevent limb amputation in the diabetic foot ulcer (DFU) population. NZWCS Conference 2022, 15-17 September Hamilton, New Zealand. Full-text available | View
- Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2022). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. John A. Boswick Burn and Wound Care Symposium January 21-26, 2022, Wailea Beach Resort – Marriott – Wailea – Maui, Hawaii. Full-text available | View
- Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2022). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. American Professional Wound Care Association, Wound Week, 2022 (February 24-27, 2022), Loews Philadelphia Hotel, Philadelphia, PA. Full-text available | View
- Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2022). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. World Union of Wound Healing Societies, 1-5 March 2022, Abu Dhabi. Full-text available | View
- Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. May (2023). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. Nurses Specialized in Wound, Ostomy and Continence Canada, May 03-07, 2023. Ottawa, Ontario, Canada Full-text available | View
- Al Mousa, R. H., B. A. Bosque and S. G. Dowling (2022). A Case Report: Utilizing Ovine Forestomach Matrix in the Subacute Treatment of Fascial Thermal Burn. World Union of Wound Healing Societies, 1-5 March 2022, Abu Dhabi. Full-text available | View
- Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2021). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. Symposium on Advanced Wound Care – Fall, 2021 (October 29-31, 2021), Las Vegas, NV. Full-text available | View
- Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2021). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. DFCon – Diabetic Global Foot Conference, October 21 – 23, 2021. San Franciso, California. Full-text available | View
- Melin, M. and C. Zeleya (2020). Chronic wound management with the innovative ovine extracellular matrix technology: a Honduran experience. Symposium on Advanced Wound Care – Spring 2020 Virtual. Full-text available | View
- Hill, R. and K. Woo (2020). Utilization of advanced antimicrobial extracellular matrix technology within the framework of antimicrobial stewardship. Symposium on Advanced Wound Care – Spring 2020 Virtual. Full-text available | View
- Duong, C. H. and J. McGuire (2020). Combination therapy of an bioresorbable synthetic polymer matrix and an ovine collagen dressing for treatment of a recurrent venous leg ulcer: A case study. Symposium on Advanced Wound Care – Fall, 2020 (Nov 4-6), Las Vegas, NV. Full-text available | View
- Zilberman, I. and N. Zolfaghari (2019). The Management of Wounds with Exposed Tendon and Bone using Innovative and Complementary Technologies: Ovine Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foams. Symposium on Advanced Wound Care – Spring, San Antonio, TX. Full-text available | View
- Zilberman, I. and N. Zolfaghari (2019). The management of wounds with exposed tendon and bone with innovative and complementary technologies: ovine extracellular matrix and gentian violet/methylene blue antibacterial foams. Symposium on Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Stillerman, J. and D. M. Freeman (2019). Using Advanced and Adaptive Technologies for the Management of Wounds – Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foam Dressing. Symposium for Advanced Wound Care – Spring, San Antonio, TX. Full-text available | View
- Woo, K., R. Raizman and R. Hill (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. Symposium on Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Raizman, R., R. Hill and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. Wounds Canada – Spring, Halifax, NS, Canada. Full-text available | View
- Morrisette, S., R. Casilang and G. Bohn (2019). Extracellular Matrix Technology for Assessing Wound Protease Concentrations Symposium of Advanced Wound Care – Spring, San Antonio, Tx. Full-text available | View
- Hill, R., R. Raizman and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. European Pressure Ulcer Advisory Panel & Société Française de l’Escarre Joint Annual Meeting 2019, Lyon, France Full-text available | View
- Hill, R., R. Raizman and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. NSWOCC 38th National Conference, Lac-Leamy, Ottawa, Canada. Full-text available | View
- Hill, R., R. Raizman and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. Wounds Canada – Fall, Niagara Falls, Ontario, Canada. Full-text available | View
- Casilang, R., E. Hicks and S. Morrisette (2019). Early Clinical Experience Using an ECM Scaffold with Ionic Silver in Diabetic Patients with Lower Extremity Ulcers. 41st Annual Boswick Burn & Wound Symposium, Wailea Beach, Maui, HI. Full-text available | View
- Zilberman, I. and N. Zolfaghari (2018). Innovative Solutions Utilizing Ovine Extracellular Matrix with Antimicrobial Silver in the Management of Wounds with Exposed Tendon and Bone. Symposium for Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Stillerman, J. (2018). Case Series Using Ovine Extracellular Matrix for the Correction of Stalled Wounds Symposium for Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Stillerman, J. (2018). To Preserve and Protect: a Dual Approach to Wound Management using an Extracellular Matrix with Ionic Silver Symposium for Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Tickner, A., C. Klinghard and K. Lussier (2018). The Use of Ovine Collagen Extracellular Matrix Dressing in the Effective Treatment of Wounds for Fast Closure and Treatment of Nerve Pain. Symposium on Advanced Wound Care – Spring, Charlotte, NC. Full-text available | View
- Silverman, A. and G. Valentine (2018). Use of Ovine Extracellular Matrix in Post-Surgical Wounds: A Case Series. Symposium for Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Mier, Y. (2018). Case Series of using collagen dressing in stalled wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC. Full-text available | View
- Morrisette, S., E. Hicks and R. Casilang (2018). Achieving Improved Wound Healing Time and Costs Savings in the Outpatient Wound Care Setting by Utilizing an Extracellular Matrix. Symposium for Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Jerome, D. and J. Clancy (2018). Incorporating advanced wound care to help restore skin health in three patients with peristomal skin complications. Wound Ostomy and Continence Nurse Conference, St. Louis, MO. Full-text available | View
- Lindberg, G. and M. Diss (2018). Complete Wound Closure in Partial Thickness Burns with the Use of Collagen Extracellular Matrix Dressings and Antibacterial Foams. Symposium on Advanced Wound Care – Spring, Charlotte, NC. Full-text available | View
- Fleck, K. A., T. Reyes and H. C. Wishall (2018). Effect of Ovine-Based Collagen Extracellular Matrix Dressings on Outcomes in an Outpatient Wound Care Center. Symposium on Advanced Wound Care – Spring, Charlotte, NC. Full-text available | View
- Gatan Mendoza, J., J. Landi and R. Rock (2018). The concurrent Use of Ovine Collagen Extracellular Matrix Dressing with Negatvie Pressure Wound Therapy on Three Acute Surgical Wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC. Full-text available | View
- Casilang, R., E. Hicks and S. Morrisette (2018). Early Clinical Experience Using an ECM Scaffold with Ionic Silver in Diabetic Patients with Lower Extremity Ulcers. Symposium for Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Aballay, A. and E. Tolchin (2018). Results of an ovine extracellular matrix dressing in the management of a variety of burns and wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC. Full-text available | View
- Andersen, C., D. Green, J. Santucci and E. Phillips (2018). Improved Venous Leg Ulcer Outcomes Using a Combination of Ovine Extracellular Matrix and Gentian Violet/Methylene Blue Transfer Antibacterial Foam. Symposium for Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Silverman, A. (2017). Use of an Ovine Collagen with an Intact Extracellular Matrix (CECM) and negative pressure wound therapy (NPWT) as part of the wound management plan following limb salvage surgical intervention in high risk diabetic foot ulcers. Symposium on Advanced Wound Care – Spring, San Diego, CA. Full-text available | View
- McIlrath, P. and J. T. Wattlers (2017). The Use of Ovine Collagen Extracellular Matrix and Gentian Violet and Methylene Blue Antibacterial Foam Dressings in the Effective Treatment of Wounds with Exposed Tendon and Bone in the High Risk Diabetic Foot. Society for Advanced Wound Care – Spring, San Diego, CA. Full-text available | View
- Vidovic, G. and P. Sykes (2016). The use of an ovine collagen extracellular matrix dressing in conjunction with negative pressure wound therapy in the management of chronic diabetic foot ulcers. Symposium on Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Zilberman, I. and N. Zolfaghari (2016). Innovative solutions in the management of wounds with exposed tendons utilizing ovine collagen extracellular matrix and gentian violet and methylene blue antibacterial foams. Symposium for Advanced Wound Care – Spring, Atlanta, GA. Full-text available | View
- Petrocelli, M. (2016). Managing Difficult Wounds Secondary to Charcot Deformity with a Novel Total Contact Cast System. Symposium on Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Petrocelli, M. Ostler, M. Liden, B. (2016). Edema reduction with a Novel Total Contact Cast System containing a Mild Compression Sock. Symposium on Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Roith, J. (2016). Managing Diabetic Foot Ulcers Using a Three Pronged Approach: V.I.P. Symposium for Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Edwards, K., White S. (2016). Use of gentian violet and methylene blue antibacterial foam dressings on various wound types in the acute care setting. Symposium on Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Ferreras, D. T., S. Craig and R. Malcomb (2016). Utilization of an ovine collagen dressing with an intact extracellular matrix (CECM) within a dual-protocol algorithm to improve wound closure times and reduce expenditures in a VA Hospital. Symposium on Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Gonzalez, A. (2016). Use of Collagen Extracellular Matrix Dressing for the Treatment of a Recurrent Venous Ulcer in a 52-Year-Old Patient. Symposium on Advanced Wound Care – Spring, Atlanta, GA. Full-text available | View
- Desvigne, M. N. (2016). Preparing a wound bed before application of cellular tissue based products using an Ovine collagen (CECM) dressing with an intact extracellular matrix. Symposium on Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Bohn, G. and S. Champion (2016). Improved Healing of Stage 3 Pressure Ulcers Using Extracellular Matrix Collagen Dressing. Symposium on Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Weir, D., D. Tedesco and G. Schultz (2015). Enhanced Clinical Effects of Combining Recombinant PDGF with Collagen Dressings in Difficult to Heal Chronic Wounds. Symposium for Advanced Wound Care – Spring, New Orleans, LA. Full-text available | View
- Pierce, B., J. Galitz, L. Hayes and M. Regan (2015). Wound Management and Estimated Cost Associated with Dermal Templates Containing 10% Extracellular Matrix Components and 90% Intact Collagen. Symposium on Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Roith, J. and T. Neill (2015). Treating Diabetic Foot Ulcer Patients with an Ovine Collagen Extra Cellular Matrix Prior to cellular Tissue Products. Annual High Risk Diabetic Foot Conference, Phoenix, AZ. Full-text available | View
- McGuire, J., N. Mahmudova and W. Lee (2015). Using becaplermin and ovine dermal template (ODT) dressing to heal chronic diabetic foot ulcers. A case series. American Podiatric Medical Association 2015 Annual Scientific Meeting (The National), Orlando, FL. Full-text available | View
- Champion, S. and G. Bohn (2015). Dressing Appearance at Change Can Give Insight into Dressing Effectiveness in the Wound. Symposium on Advances in Skin & Wound Care – Spring, New Orleans, LA. Full-text available | View
- Desvigne, M. N. (2015). Ovine collagen extracellular matrix (CECM) Dressing Assisted Closure: For the Acute Wound, Following Mohs Surgical Excision. Clinical Symposium on Advances in Skin & Wound Care. New Orleans, LA. Full-text available | View
- Zilberman, I. and N. Zolfaghari (2014). Use of ovine collagen extracellular matrix (CECM) dressing and gentian violet and methylene blue (GV/MB) antimicrobial foam dressing in the management of diabetic foot ulcers. Symposium on Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Lullove (2014). Pilot series of recalcitrant lower extremity wounds managed with an ovine collagen extracellular matrix (CECM) and gentian violet/methylene blue (GV/MB) antibacterial foam dressings. Symposium on Advanced Wound Care – Fall, Las Vegas, NV. Full-text available | View
- Wright, K., D. Hastings, W. Dukes and K. Gorgui (2013). Innovative Dressing Option: Use of a collagen dermal template with extracellular matrix (ECM)* in the management of lower extremity wounds. Clinical Symposium on Advances in Skin & Wound Care, Orlando, FL. Full-text available | View
- Pompeo, M., K. Neeley and L. Garner (2013). Utilizing a collagen dermal template in various wound etiologies yielded positive results in an outpatient wound care center. Symposium on Advanced Wound Care – Spring, Denver, CO. Full-text available | View
- Miller, S. D., K. Trotter, B. Hong, R. Lenz, D. Nagesh, H. K. Park and M. Garoufalis (2013). An Approach to Treating Neuropathic Pedal Ulcerations with Ovine Collagen Extracellular Matrix (CECM). Symposium on Advanced Wound Care – Spring, Denver, CO. Full-text available | View
- Lullove, E. (2013). Use of a collagen dermal template with extracellular matrix (ECM) to treat complex lower extremity wounds. Clinical Symposium on Advances in Skin & Wound Care, Orlando, FL. Full-text available | View
- Curran, M., C. Rodriquez, O. J. Altschul, A. Fragen and F. Ercoll (2013). The Use of collagen dermal template with an ECM in various wounds in acute care and outpatient wound care settings. Symposium on Advanced Wound Care – Spring, Denver, CO Full-text available | View
- Liden, B., B. R. Ward and B. C. H. May (2011). Early Clinical Findings from the Use of Ovine Forestomach Matrix to Treat Recalcirant Wounds. Symposium on Advanced Wound Care – Spring, Dallas, Tx. Full-text available | View
Peer-Reviewed Publications
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- Bohn, G. A. (2023). “Key concepts in healing venous leg ulcers.” Wounds 35(Suppl 5): S1-S6. Full-text available | View
- Melnychuk, I., I. Servetnyk and N. Kosnik (2023). “Extracellular Matrix–Based Collagen Dressings for Scalp Repair Following Mohs Micrographic Surgery.” Cutis 111(5): e33-e35. Full-text available | View
- Sharma, A., D. Sharma, and F. Zhao. 2023. ‘Updates on Recent Clinical Assessment of Commercial Chronic Wound Care Products’, Advanced Healthcare Materials, Jun 12: e2300556. Full-text available | View
- Bosque, B. A., C. Frampton, A. E. Chaffin, G. A. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2022). “Retrospective real-world comparative effectiveness of ovine forestomach matrix and collagen/ORC in the treatment of diabetic foot ulcers.” Int Wound J 19(4): 741-753. Full-text available | View
- Nair, H. K. R., B. A. Bosque and S. G. Dowling (2022). “Use of an advanced extracellular matrix dressing in the treatment of acute and chronic wounds: a Malaysian case series.” Wounds Asia 5(1): 40 – 46. Full-text available | View
- Al Mousa, R. H., B. A. Bosque and S. G. Dowling (2022). “Use of ovine forestomach matrix in the treatment of facial thermal burns.” Wounds 34(4): e17-21. Full-text available | View
- Boyar, V. (2021). “Association of Systemic or Intravitreal Antivascular Endothelial Growth Factor (Anti-VEGF) and Impaired Wound Healing in Pediatric Patients: Collagen to the Rescue.” J Wound Ostomy Continence Nurs 48(3): 256-261. Full-text available | View
- Blevins, M. (2021). “Atypical Ulcerative Necrobiosis Lipoidica Diabeticorum: A Case Study.” Int J Low Extrem Wounds: 1534734621999269. Full-text available | View
- Raizman, R., R. Hill and K. Woo (2020). “Prospective Multicenter Evaluation of an Advanced Extracellular Matrix for Wound Management.” Adv Skin Wound Care 33(8): 437-444. Full-text available | View
- S. Morrisette (2019). “Using Endoform as a Protease Indicator to Standardize Wound Management.” Wound Management and Prevention 65(8): 8-10. Full-text available | View
- Boyar, V. (2019). “Collagen: providing a key to the wound healing kingdom.” Wound Management and Prevention 65(8): 12-14. Full-text available | View
- Casilang, R. and S. Morrisette (2019). “Utilizing Endoform as a Surrogate Marker of Wound Protease Levels in Chronic Wounds.” Wound Management and Prevention 65(5): 8-10. Full-text available | View
- Bohn, G. (2019). “Complex Problem, Simple Solution: Using Endoform to Provide a Functional Extracellular Matrix in Chronic Wounds.” Wound Management and Prevention 65(10): 8-10. Full-text available | View
- Bohn, G. A. (2019). “Endoform: A Simple Tool to Assess Wound Proteases.” Wound Management and Prevention 65(3): 18-20. Full-text available | View
- Zilberman, I. and N. Zolfaghari (2018). “Taking the Guess Work Out of Silver Use.” Ostomy and Wound Management October 2018: 12-14. Full-text available | View
- Zilberman, I. and N. Zolfaghari (2018). “Adding an Antimicrobial With Silver to Your Wound Care Armamentarium.” Ostomy and Wound Management August 2018: 10-11. Full-text available | View
- Edwards, K. (2018). “Collaborating with WOC Nurses to Optimize Patient Progress.” Ostomy and Wound Management May 2018: 10-12. Full-text available | View
- Gonzalez, A. (2018). “Managing Pressure Injuries in Home Health Care.” Ostomy and Wound Management 64(4): 12-14. Full-text available | View
- Lullove, E. J. (2017). “Use of Ovine-based Collagen Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foam Dressings to Help Improve Clinical Outcomes in Lower Extremity Wounds: A Retrospective Cohort Study.” Wounds 29(4): 107-114. Full-text available | View
- Ferreras, D. T. (2017). “Wound Bed Preparation: Is It Time to Up Your Game?” Ostomy and Wound Management 63(12): 10-11. Full-text available | View
- Ferreras, D. T., S. Craig and R. Malcomb (2017). “Use of an Ovine Collagen Dressing with Intact Extracellular Matrix to Improve Wound Closure Times and Reduce Expenditures in a US Military Veteran Hospital Outpatient Wound Center.” Surg Technol Int 30: 61-69. Full-text available | View
- Bohn, G. A., G. S. Schultz, B. A. Liden, M. N. Desvigne, E. J. Lullove, I. Zilberman, M. B. Regan, M. Ostler, K. Edwards, G. M. Arvanitis and J. F. Hartman (2017). “Proactive and Early Aggressive Wound Management: A Shift in Strategy Developed by a Consensus Panel Examining the Current Science, Prevention, and Management of Acute and Chronic Wounds.” Wounds 29(11): S37-S42. Full-text available | View
- Gonzalez, A. (2016). “Use of Collagen Extracellular Matrix Dressing for the Treatment of a Recurrent Venous Ulcer in a 52-Year-Old Patient.” J Wound Ostomy Continence Nurs 43(3): 310-312. Full-text available | View
- Bohn, G., B. Liden, G. Schultz, Q. Yang and D. J. Gibson (2016). “Ovine-Based Collagen Matrix Dressing: Next-Generation Collagen Dressing for Wound Care.” Adv Wound Care (New Rochelle) 5(1): 1-10. Full-text available | View
- Goss, S. G., S. D. Alcantara and J. C. Lantis Ii (2014). “Office based therapies for complex lower extremity epithelial defects.” Surg Technol Int 24: 91-98. Full-text available | View
- Sibbald, R. G., L. G. Ovington, E. A. Ayello, L. Goodman and J. A. Elliott (2014). “Wound bed preparation 2014 update: management of critical colonization with a gentian violet and methylene blue absorbent antibacterial dressing and elevated levels of matrix metalloproteases with an ovine collagen extracellular matrix dressing.” Adv Skin Wound Care 27(3 Suppl 1): 1-6. Full-text available | View
- Bohn, G. A. and K. Gass (2014). “Leg ulcer treatment outcomes with new ovine collagen extracellular matrix dressing: a retrospective case series.” Adv Skin Wound Care 27(10): 448-454. Full-text available | View
- Simcock, J. and B. C. May (2013). “Ovine forestomach matrix as a substrate for single-stage split-thickness graft reconstruction.” Eplasty 13: e58. Full-text available | View
- Simcock, J. W., M. Than, B. R. Ward and B. C. May (2013). “Treatment of ulcerated necrobiosis lipoidica with ovine forestomach matrix.” J Wound Care 22(7): 383-384. Full-text available | View
- Liden, B. A. and B. C. May (2013). “Clinical outcomes following the use of ovine forestomach matrix (endoform dermal template) to treat chronic wounds.” Adv Skin Wound Care 26. Full-text available | View
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Reimbursement
This page is dedicated to reimbursement information and support for our products. Should you wish to speak to one of our specialist reimbursement support team, please contact us on:
- reimbursement@aroa.com
- 1800 AROA ECM (1-800-2762-326)
- Fax: +1 877-775-3157
Should you require additional or more comprehensive information, please find it available on the Centers for Medicare and Medicaid Services website.
Disclaimer: The information provided is offered as general information only and should not be construed as providing clinical advice, dictating reimbursement policy or substituting for the judgment of a healthcare provider. While Aroa Biosurgery Limited has taken reasonable efforts to provide accurate information regarding Medicare payment rates specified for items and services related to its products, it shall not be liable for the accuracy or completeness of the information in this guide. Aroa Biosurgery Limited provides this guide as a frame of reference for providers only and does not assume any responsibility for coding decisions, nor does it recommend codes for specific patient procedures. Nothing contained herein guarantees coverage by Medicare or other payers. Providers are always responsible for: (1) consulting with their payors, coding specialists, and/or legal counsel regarding any coverage, coding, or payment issues; (2) checking current reimbursement laws, regulations and payor policies; and (3) determining and submitting appropriate codes, charges and modifiers for goods and services it provides.
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