Overview

Overview

Endoform™ Antimicrobial Restorative Bioscaffold and Endoform™ Natural Restorative Bioscaffold are unique extracellular matrix (ECM) products for the management of acute and chronic wounds. Endoform™ products support all phases of wound healing and are appropriate for use early in wound management to restore protease balance and advance healing to the proliferative phase.(1)

Endoform™ products:

  • Provide a natural porous ECM bioscaffold for rapid cell infiltration(2)
  • Contains more than 150 ECM proteins known to be important in wound healing(3)
  • Contain residual vascular channels to support the establishment of new vasculature(4)
  • Can indicate the presence or absence of proteases and help restore protease balance and guide re-application(5)
  • Can be used by any wound care provider from day 1(1)

Endoform™ Antimicrobial Restorative Bioscaffold contains 0.3% ionic silver, appropriate for use in early acute and chronic wound management where there is an elevated risk of infection.

  • Provides broad spectrum antimicrobial activity for up to 7 days*(6)
  • Prevents biofilm formation(6)
  • Is non-cytotoxic to dermal cells(6)

*Endoform™ Antimicrobial contains 0.3% ionic silver to protect the dressing from microbial colonization

Ionic silver have been included in the Endoform™ Antimicrobial to protect the device from microbial contamination. Reduction in colonization or microbial growth on the device has not been shown to correlate with a reduction in infections in patients. Clinical studies to evaluate reduction in infection have not been performed.

Please contact your local sales representative or distributer to see what products are available to you.

1. Ferreras, D. T., S. et al. Surg Technol Int 30: 61-69. 2. G. A. Bohn, G. S. et al. Wounds, 29(11), S37-S42 (2017). 3. Bosque, B. A. et al. Int Wound J 2021 Aug 6 (Epub ahead of print).
4. Negron et al. Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase.

1. G. A. Bohn, G. S. Schultz, B. A. Liden, M. N. Desvigne, E. J. Lullove, I. Zilberman, M. B. Regan, M. Ostler, K. Edwards, G. M. Arvanitis and J. F. Hartman: Proactive and Early Aggressive Wound Management: A Shift in Strategy Developed by a Consensus Panel Examining the Current Science, Prevention, and Management of Acute and Chronic Wounds. Wounds, 29(11), S37-S42 (2017). 2. S. Lun, S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. May: A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 31(16), 4517-29 (2010) doi:10.1016/j.biomaterials.2010.02.025. 3. S. G. Dempsey, C. H. Miller, R. C. Hill, K. C. Hansen and B. C. H. May: Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix. J Proteome Res, 18(4), 1657-1668 (2019) doi:10.1021/acs.jproteome.8b00908. 4. Smith MJ, Dempsey SG, Veale RW, et al. Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair. Journal of Biomaterials Applications. 2022;36(6):996-1010. doi:10.1177/08853282211045770. 5. G. A. Bohn: Endoform: A Simple Tool to Assess Wound Proteases. Wound Management and Prevention, 65(3), 18-20 (2019). 6. T. Karnik, S. G. Dempsey, M. J. Jerram, A. Nagarajan, R. Rajam, B. C. H. May and C. H. Miller: Ionic silver functionalized ovine forestomach matrix – a non-cytotoxic antimicrobial biomaterial for tissue regeneration applications. Biomater Res, 23, 6 (2019) doi:10.1186/s40824-019-0155-0

How It Works

How It Works

Endoform™ Antimicrobial and Endoform™ Natural Restorative Bioscaffold products work in all phases of healing to stabilize, correct, build and organize tissue.

Endoform™ products are made from AROA ECM™ technology and contain more than 150 extracellular matrix (ECM) proteins that enable it to interact with patient’s cells throughout all phases of healing.(1, 2) Endoform™ products are 85% collagen and 15% important secondary molecules, including structural and adhesion proteins, and glycosaminoglycans (GAGs).(1) Endoform™ products only contain components found in tissue extracellular matrix.

During the inflammatory phase, chronic wounds are characterized by elevated wound proteases that limit healing by digesting important dermal proteins.(3) Endoform™ products can help indicate the presence or absence of proteases and restores protease balance.(4, 5)  If Endoform™ products are not visible in the wound bed at the time of reapplication, this can indicate elevated wound protease activity. However, if Endoform™ is visible, this can indicate that protease balance has been restored.

Endoform™ products also contain residual vascular channels that facilitate the rapid establishment of a dense capillary network by supporting migrating endothelial cells to establish new vasculature and a robust blood supply to help build new tissue.(6) This process is termed angioconduction.

1. S. Lun, S.M. Irvine, K.D. Johnson, N.J. Fisher, E.W. Floden, L. Negron, S.G. Dempsey, R.J. McLaughlin, M. Vasudevamurthy, B.R. Ward, B.C. May, A functional extracellular matrix biomaterial derived from ovine forestomach, Biomaterials 31(16) (2010) 4517-29. 2. S.G. Dempsey, C.H. Miller, R.C. Hill, K.C. Hansen, B.C.H. May, Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix, J Proteome Res 18(4) (2019) 1657-1668. 3. R. Lobmann, A. Ambrosch, G. Schultz, K. Waldmann, S. Schiweck, H. Lehnert, Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients, Diabetologia 45(7) (2002) 1011-6. 4. G.A. Bohn, Endoform: A Simple Tool to Assess Wound Proteases, Wound Management and Prevention 65(3) (2019) 18-20. 5. L. Negron, S. Lun, B.C.H. May, Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase, Int Wound J 11(4) (2012) 392-397. 6. Data on file.

Formats

Formats

Indications

Indications

Endoform™ Antimicrobial Restorative Bioscaffold and Endoform™ Natural Restorative Bioscaffold products are indicated for the management of acute and chronic wounds including:

  • Partial and full thickness wounds
  • Pressure ulcers
  • Venous ulcers
  • Diabetic ulcers
  • Chronic vascular ulcers
  • Tunneled/undermined wounds
  • Surgical wounds (donor sites, grafts, post Moh’s surgery, post laser surgery, podiatric, wound dehiscence)
  • Traumatic wounds (abrasions, lacerations, second-degree burns, and skin tears)
  • Draining wounds
Clinical Evidence

Clinical Evidence

Peer-Reviewed Clinical Studies

2022

Nair, H. K. R., B. A. Bosque and S. G. Dowling (2022). “Use of an advanced extracellular matrix dressing in the treatment of acute and chronic wounds: a Malaysian case series.” Wounds Asia 5(1): 40 – 46.

Full-text available | View

Al Mousa, R. H., B. A. Bosque and S. G. Dowling (2022). “Use of ovine forestomach matrix in the treatment of facial thermal burns.” Wounds 34(4): e17-21.

Full-text available | View

2021

Bosque, B. A., C. Frampton, A. E. Chaffin, G. A. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2021). “Retrospective real-world comparative effectiveness of ovine forestomach matrix and collagen/ORC in the treatment of diabetic foot ulcers.” Int Wound J 2021 Aug 6 (Epub ahead of print).

Full-text available | View

Boyar, V. (2021). “Association of Systemic or Intravitreal Antivascular Endothelial Growth Factor (Anti-VEGF) and Impaired Wound Healing in Pediatric Patients: Collagen to the Rescue.” J Wound Ostomy Continence Nurs 48(3): 256-261.

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Blevins, M. (2021). “Atypical Ulcerative Necrobiosis Lipoidica Diabeticorum: A Case Study.” Int J Low Extrem Wounds: 1534734621999269.

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2020

Raizman R, Hill R, Woo K. Prospective Multicenter Evaluation of an Advanced Extracellular Matrix for Wound Management [published online ahead of print, 2020 May 27]. Adv Skin Wound Care 33(8): 437-444.

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2017

Lullove, E. J. (2017). “Use of Ovine-based Collagen Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foam Dressings to Help Improve Clinical Outcomes in Lower Extremity Wounds: A Retrospective Cohort Study.” Wounds 29(4): 107-114.

Full-text available | View

Ferreras, D. T., S. Craig and R. Malcomb (2017). “Use of an Ovine Collagen Dressing with Intact Extracellular Matrix to Improve Wound Closure Times and Reduce Expenditures in a US Military Veteran Hospital Outpatient Wound Center.” Surg Technol Int 30: 61-69.

Full-text available | View

2016

Gonzalez, A. (2016). “Use of Collagen Extracellular Matrix Dressing for the Treatment of a Recurrent Venous Ulcer in a 52-Year-Old Patient.” J Wound Ostomy Continence Nurs 43(3): 310-312.

Abstract only | View

2014

Bohn, G. A. and K. Gass (2014). “Leg ulcer treatment outcomes with new ovine collagen extracellular matrix dressing: a retrospective case series.” Adv Skin Wound Care 27(10): 448-454.

Abstract only | View

2013

Simcock, J. W., M. Than, B. R. Ward and B. C. May (2013). “Treatment of ulcerated necrobiosis lipoidica with ovine forestomach matrix.” J Wound Care 22(7): 383-384.

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Simcock, J. and B. C. May (2013). “Ovine forestomach matrix as a substrate for single-stage split-thickness graft reconstruction.” Eplasty 13: e58.

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Liden, B. A. and B. C. May (2013). “Clinical outcomes following the use of ovine forestomach matrix (endoform dermal template) to treat chronic wounds.” Adv Skin Wound Care 26.

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Conference Proceedings

2023

Blasina, M. (2023). Use of ECM Scaffold Derived From Ovine Forestomach: An Italian Experience in Outpatient and Inpatient Settings. European Wound Management Association, 03-05 May, 2023. Milan, Italy.

Scarpa, C. (2023). The Ovine Extracellular Matrix in Acute and Chronic Wounds: Our Preliminary Experience. European Wound Management Association, 03-05 May, 2023. Milan, Italy.

Bosque, B. A., C. Frampton, A. E. Chaffin, G. A. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2023). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. European Wound Management Association, 03-05 May, 2023. Milan, Italy.

Full-text available | View

Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. May (2023). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. Nurses Specialized in Wound, Ostomy and Continence Canada, May 03-07, 2023. Ottawa, Ontario, Canada.

Full-text available | View

2022

Gilleece, D. and A. Sutton (2022). Extracellular matrix technology as an adjunct to prevent limb amputation in the diabetic foot ulcer (DFU) population. NZWCS Conference 2022, 15-17 September Hamilton, New Zealand.

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Morgan, B. (2022). Advanced ECM technology for the treatment of surgical wounds resulting from a recurrent pressure injury. NZWCS Conference 2022, 15-17 September Hamilton, New Zealand.

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Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2022). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. World Union of Wound Healing Societies, 1-5 March 2022, Abu Dhabi.

Full-text available | View

Al Mousa, R. H., B. A. Bosque and S. G. Dowling (2022). A Case Report: Utilizing Ovine Forestomach Matrix in the Subacute Treatment of Fascial Thermal Burn. World Union of Wound Healing Societies, 1-5 March 2022, Abu Dhabi.

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Geiger, J. E. J., R. Kaufman, I. Zilberman, N. Zolfaghari, W. Dutch and B. A. Bosque (2022). Continuity of Care: Retrospective Review of Ovine Forestomach Matrix Efficacy Across All Phases of Wound Healing. Symposium on Advanced Wound Care – Spring 2022, April 6-10, 2022, Phoenix, AZ.

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Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2022). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. American Professional Wound Care Association, Wound Week, 2022 (Feburary 24-27, 2022), Loews Philadelphia Hotel, Philadelphia, PA.

Full-text available | View

Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2022). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. John A. Boswick Burn and Wound Care Symposium January 21-26, 2022, Wailea Beach Resort – Marriott – Wailea – Maui, Hawaii.

Full-text available | View

2021

Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2021). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. Symposium on Advanced Wound Care – Fall, 2021 (October 29-31, 2021), Las Vegas, NV.

Full-text available | View

Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2021). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. DFCon – Diabetic Global Foot Conference, October 21 – 23, 2021. San Franciso, California.

Full-text available | View

2020

Duong, C. H. and J. McGuire (2020). Combination therapy of an bioresorbable synthetic polymer matrix and an ovine collagen dressing for treatment of a recurrent venous leg ulcer: A case study. Symposium on Advanced Wound Care – Fall, 2020 (Nov 4-6), Las Vegas, NV.

Full-text available | View

Melin, M. and C. Zeleya (2020). Chronic wound management with the innovative ovine extracellular matrix technology: a Honduran experience. Symposium on Advanced Wound Care – Spring 2020 Virtual.

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Hill, R. and K. Woo (2020). Utilization of advanced antimicrobial extracellular matrix technology within the framework of antimicrobial stewardship. Symposium on Advanced Wound Care – Spring 2020 Virtual.

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2019

Casilang, R., E. Hicks and S. Morrisette (2019). Early Clinical Experience Using an ECM Scaffold with Ionic Silver in Diabetic Patients with Lower Extremity Ulcers. 41st Annual Boswick Burn & Wound Symposium, Wailea Beach, Maui, HI.

Full-text available | View

Raizman, R., R. Hill and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. Wounds Canada – Spring, Halifax, NS, Canada.

Full-text available | View

Hill, R., R. Raizman and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. NSWOCC 38th National Conference, Lac-Leamy, Ottawa, Canada.

Full-text available | View

Stillerman, J. and D. M. Freeman (2019). Using Advanced and Adaptive Technologies for the Management of Wounds – Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foam Dressing. Symposium for Advanced Wound Care – Spring, San Antonio, TX.

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Zilberman, I. and N. Zolfaghari (2019). The Management of Wounds with Exposed Tendon and Bone using Innovative and Complementary Technologies: Ovine Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foams. Symposium on Advanced Wound Care – Spring, San Antonio, TX.

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Morrisette, S., R. Casilang and G. Bohn (2019). Extracellular Matrix Technology for Assessing Wound Protease Concentrations Symposium of Advanced Wound Care – Spring, San Antonio, Tx.

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Zilberman, I. and N. Zolfaghari (2019). The management of wounds with exposed tendon and bone with innovative and complementary technologies: ovine extracellular matrix and gentian violet/methylene blue antibacterial foams. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

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Woo, K., R. Raizman and R. Hill (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

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Hill, R., R. Raizman and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. Wounds Canada – Fall, Niagara Falls, Ontario, Canada.

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Hill, R., R. Raizman and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. European Pressure Ulcer Advisory Panel & Société Française de l’Escarre Joint Annual Meeting 2019, Lyon, France

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2018

Zilberman, I. and N. Zolfaghari (2018). Innovative Solutions Utilizing Ovine Extracellular Matrix with Antimicrobial Silver in the Management of Wounds with Exposed Tendon and Bone. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

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Stillerman, J. (2018). To Preserve and Protect: a Dual Approach to Wound Management using an Extracellular Matrix with Ionic Silver Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Casilang, R., E. Hicks and S. Morrisette (2018). Early Clinical Experience Using an ECM Scaffold with Ionic Silver in Diabetic Patients with Lower Extremity Ulcers. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Stillerman, J. (2018). Case Series Using Ovine Extracellular Matrix for the Correction of Stalled Wounds Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

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Silverman, A. and G. Valentine (2018). Use of Ovine Extracellular Matrix in Post-Surgical Wounds: A Case Series. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

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Morrisette, S., E. Hicks and R. Casilang (2018). Achieving Improved Wound Healing Time and Costs Savings in the Outpatient Wound Care Setting by Utilizing an Extracellular Matrix. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

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Andersen, C., D. Green, J. Santucci and E. Phillips (2018). Improved Venous Leg Ulcer Outcomes Using a Combination of Ovine Extracellular Matrix and Gentian Violet/Methylene Blue Transfer Antibacterial Foam. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

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Tickner, A., C. Klinghard and K. Lussier (2018). The Use of Ovine Collagen Extracellular Matrix Dressing in the Effective Treatment of Wounds for Fast Closure and Treatment of Nerve Pain. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

Gatan Mendoza, J., J. Landi and R. Rock (2018). The concurrent Use of Ovine Collagen Extracellular Matrix Dressing with Negatvie Pressure Wound Therapy on Three Acute Surgical Wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

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Mier, Y. (2018). Case Series of using collagen dressing in stalled wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

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Lindberg, G. and M. Diss (2018). Complete Wound Closure in Partial Thickness Burns with the Use of Collagen Extracellular Matrix Dressings and Antibacterial Foams. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

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Jerome, D. and J. Clancy (2018). Incorporating advanced wound care to help restore skin health in three patients with peristomal skin complications. Wound Ostomy and Continence Nurse Conference, St. Louis, MO.

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Fleck, K. A., T. Reyes and H. C. Wishall (2018). Effect of Ovine-Based Collagen Extracellular Matrix Dressings on Outcomes in an Outpatient Wound Care Center. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

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Aballay, A. and E. Tolchin (2018). Results of an ovine extracellular matrix dressing in the management of a variety of burns and wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

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2017

Silverman, A. (2017). Use of an Ovine Collagen with an Intact Extracellular Matrix (CECM) and negative pressure wound therapy (NPWT) as part of the wound management plan following limb salvage surgical intervention in high risk diabetic foot ulcers. Symposium on Advanced Wound Care – Spring, San Diego, CA.

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McIlrath, P. and J. T. Wattlers (2017). The Use of Ovine Collagen Extracellular Matrix and Gentian Violet and Methylene Blue Antibacterial Foam Dressings in the Effective Treatment of Wounds with Exposed Tendon and Bone in the High Risk Diabetic Foot. Society for Advanced Wound Care – Spring, San Diego, CA.

Full-text available | View

2016

Zilberman, I. and N. Zolfaghari (2016). Innovative solutions in the management of wounds with exposed tendons utilizing ovine collagen extracellular matrix and gentian violet and methylene blue antibacterial foams. Symposium for Advanced Wound Care – Spring, Atlanta, GA.

Full-text available | View

Vidovic, G. and P. Sykes (2016). The use of an ovine collagen extracellular matrix dressing in conjunction with negative pressure wound therapy in the management of chronic diabetic foot ulcers. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

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Roith, J. (2016). Managing Diabetic Foot Ulcers Using a Three Pronged Approach: V.I.P. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

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Petrocelli, M. (2016). Managing Difficult Wounds Secondary to Charcot Deformity with a Novel Total Contact Cast System. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

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Petrocelli, M. Ostler, M. Liden, B. (2016). Edema reduction with a Novel Total Contact Cast System containing a Mild Compression Sock. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

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Gonzalez, A. (2016). Use of Collagen Extracellular Matrix Dressing for the Treatment of a Recurrent Venous Ulcer in a 52-Year-Old Patient. Symposium on Advanced Wound Care – Spring, Atlanta, GA.

Full-text available | View

Ferreras, D. T., S. Craig and R. Malcomb (2016). Utilization of an ovine collagen dressing with an intact extracellular matrix (CECM) within a dual-protocol algorithm to improve wound closure times and reduce expenditures in a VA Hospital. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Edwards, K., White S. (2016). Use of gentian violet and methylene blue antibacterial foam dressings on various wound types in the acute care setting. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

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Desvigne, M. N. (2016). Preparing a wound bed before application of cellular tissue based products using an Ovine collagen (CECM) dressing with an intact extracellular matrix. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

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Bohn, G. and S. Champion (2016). Improved Healing of Stage 3 Pressure Ulcers Using Extracellular Matrix Collagen Dressing. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

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2015

Weir, D., D. Tedesco and G. Schultz (2015). Enhanced Clinical Effects of Combining Recombinant PDGF with Collagen Dressings in Difficult to Heal Chronic Wounds. Symposium for Advanced Wound Care – Spring, New Orleans, LA.

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Roith, J. and T. Neill (2015). Treating Diabetic Foot Ulcer Patients with an Ovine Collagen Extra Cellular Matrix Prior to cellular Tissue Products. Annual High Risk Diabetic Foot Conference, Phoenix, AZ.

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Pierce, B., J. Galitz, L. Hayes and M. Regan (2015). Wound Management and Estimated Cost Associated with Dermal Templates Containing 10% Extracellular Matrix Components and 90% Intact Collagen. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

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McGuire, J., N. Mahmudova and W. Lee (2015). Using becaplermin and ovine dermal template (ODT) dressing to heal chronic diabetic foot ulcers. A case series. American Podiatric Medical Association 2015 Annual Scientific Meeting (The National), Orlando, FL.

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Desvigne, M. N. (2015). Ovine collagen extracellular matrix (CECM) Dressing Assisted Closure: For the Acute Wound, Following Mohs Surgical Excision. Clinical Symposium on Advances in Skin & Wound Care. New Orleans, LA.

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Champion, S. and G. Bohn (2015). Dressing Appearance at Change Can Give Insight into Dressing Effectiveness in the Wound. Symposium on Advances in Skin & Wound Care – Spring, New Orleans, LA.

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2014

Zilberman, I. and N. Zolfaghari (2014). Use of ovine collagen extracellular matrix (CECM) dressing and gentian violet and methylene blue (GV/MB) antimicrobial foam dressing in the management of diabetic foot ulcers. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Full-text available | View

Lullove (2014). Pilot series of recalcitrant lower extremity wounds managed with an ovine collagen extracellular matrix (CECM) and gentian violet/methylene blue (GV/MB) antibacterial foam dressings. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

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Blaszcyk, J. and A. McIntosh (2014). The effectiveness of an ovine collagen extracellular matrix dressing for chronic non-healing wounds. Symposium on Advanced Wound Care – Spring, Denver, CO.

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2013

Wright, K., D. Hastings, W. Dukes and K. Gorgui (2013). Innovative Dressing Option: Use of a collagen dermal template with extracellular matrix (ECM)* in the management of lower extremity wounds. Clinical Symposium on Advances in Skin & Wound Care, Orlando, FL.

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Pompeo, M., K. Neeley and L. Garner (2013). Utilizing a collagen dermal template in various wound etiologies yielded positive results in an outpatient wound care center. Symposium on Advanced Wound Care – Spring, Denver, CO.

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Miller, S. D., K. Trotter, B. Hong, R. Lenz, D. Nagesh, H. K. Park and M. Garoufalis (2013). An Approach to Treating Neuropathic Pedal Ulcerations with Ovine Collagen Extracellular Matrix (CECM). Symposium on Advanced Wound Care – Spring, Denver, CO.

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Lullove, E. (2013). Use of a collagen dermal template with extracellular matrix (ECM) to treat complex lower extremity wounds. Clinical Symposium on Advances in Skin & Wound Care, Orlando, FL.

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Curran, M., C. Rodriquez, O. J. Altschul, A. Fragen and F. Ercoll (2013). The Use of collagen dermal template with an ECM in various wounds in acute care and outpatient wound care settings. Symposium on Advanced Wound Care – Spring, Denver, CO

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2011

Liden, B., B. R. Ward and B. C. H. May (2011). Early Clinical Findings from the Use of Ovine Forestomach Matrix to Treat Recalcirant Wounds. Symposium on Advanced Wound Care – Spring, Dallas, Tx.

Full-text available | View

Clinical Consensus Papers

2019

Bohn, G. A. (2019). “Endoform: A Simple Tool to Assess Wound Proteases.” Wound Management and Prevention 65(3): 18-20.

Full-text available | View

Casilang, R. and S. Morrisette (2019). “Utilizing Endoform as a Surrogate Marker of Wound Protease Levels in Chronic Wounds.” Wound Management and Prevention 65(5): 8-10.

Full-text available | View

S. Morrisette (2019). “Using Endoform as a Protease Indicator to Standardize Wound Management.” Wound Management and Prevention 65(8): 8-10.

Full-text available | View

Bohn, G. (2019). “Complex Problem, Simple Solution: Using Endoform to Provide a Functional Extracellular Matrix in Chronic Wounds.” Wound Management and Prevention 65(10): 8-10.

Full-text available | View

Boyar, V. (2019). “Collagen: providing a key to the wound healing kingdom.” Wound Management and Prevention 65(8): 12-14.

Full-text available | View

2018

Zilberman, I. and N. Zolfaghari (2018). “Adding an Antimicrobial With Silver to Your Wound Care Armamentarium.” Ostomy and Wound Management August 2018: 10-11.

Abstract only | View

Zilberman, I. and N. Zolfaghari (2018). “Taking the Guess Work Out of Silver Use.” Ostomy and Wound Management October 2018: 12-14.

Abstract only | View

Gonzalez, A. (2018). “Managing Pressure Injuries in Home Health Care.” Ostomy and Wound Management 64(4): 12-14.

Abstract only | View

Edwards, K. (2018). “Collaborating with WOC Nurses to Optimize Patient Progress.” Ostomy and Wound Management May 2018: 10-12.

Abstract only | View

2017

Ferreras, D. T. (2017). “Wound Bed Preparation: Is It Time to Up Your Game?” Ostomy and Wound Management 63(12): 10-11.

Abstract only | View

Bohn, G. A., G. S. Schultz, B. A. Liden, M. N. Desvigne, E. J. Lullove, I. Zilberman, M. B. Regan, M. Ostler, K. Edwards, G. M. Arvanitis and J. F. Hartman (2017). “Proactive and Early Aggressive Wound Management: A Shift in Strategy Developed by a Consensus Panel Examining the Current Science, Prevention, and Management of Acute and Chronic Wounds.” Wounds 29(11): S37-S42.

Full-text available | View

2016

Bohn, G., B. Liden, G. Schultz, Q. Yang and D. J. Gibson (2016). “Ovine-Based Collagen Matrix Dressing: Next-Generation Collagen Dressing for Wound Care.” Adv Wound Care (New Rochelle) 5(1): 1-10.

Full-text available | View

2014

Sibbald, R. G., L. G. Ovington, E. A. Ayello, L. Goodman and J. A. Elliott (2014). “Wound bed preparation 2014 update: management of critical colonization with a gentian violet and methylene blue absorbent antibacterial dressing and elevated levels of matrix metalloproteases with an ovine collagen extracellular matrix dressing.” Adv Skin Wound Care 27(3 Suppl 1): 1-6.

Abstract only | View

Pre-Clinical Literature

2019

Karnik, T., S. G. Dempsey, M. J. Jerram, A. Nagarajan, R. Rajam, B. C. H. May and C. H. Miller (2019). “Ionic silver functionalized ovine forestomach matrix – a non-cytotoxic antimicrobial biomaterial for tissue regeneration applications.” Biomater Res 23: 6

Full-text available | View

Product Resources

Product Resources

Video Library

AROA ECM™- Mode of Action

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Endoform™ Antimicrobial – An Advanced ECM ‘right at home’ in Home Health

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Endoform™ – Empowering Nursing with an Advanced ECM

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Endoform™ – An Extracellular Matrix Optimized for NPWT

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Endoform™ Real-World Data Analysis

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Endoform™ Around the World

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AROA ECM™ – Unlocking regenerative healing for everybody

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Endoform™ Post Surgical Pressure Injury

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Endoform™ Case Study Full Thickness Wound

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Endoform™ Mechanism of Action

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Endoform™ Application Guide

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Aroa Biosurgery – Unlocking regenerative healing for everybody

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Downloadable Documents
Endoform Product Overview

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Endoform™ Antimicrobial IFU

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Tissue Extracellular Matrix (ECM) Brochure

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Endoform™ – Real-World Data Analysis

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The Impact of Endoform™ on CTP Usage – Clinical Evidence

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Endoform™ Natural Brochure

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Endoform™ and Negative Pressure Wound Therapy Brochure

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Endoform™ Natural IFU

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Endoform™ Antimicrobial Brochure

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Endoform™ Natural Large High Flow & Endoform™ Presentations

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Residual Endoform™ Brochure

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