Myriad Matrix™ is an engineered extracellular matrix (ECM) for soft tissue repair, reinforcement and complex wounds. Myriad Matrix™ has been specifically designed to help maximize tissue repair while providing versatility and adaptability across a wide range of surgical applications.
Myriad Matrix™ is designed to be easily customizable for a wide range of anatomical sites and surgical needs and can be used in both implantation and dermal repair.
Myriad Matrix™ devices contain the natural porous structure of AROA ECM™, engineered with interstitial perforations to enable cell infiltration to facilitate rapid healing.
Fast absorption of blood & cells accelerates host cell infiltration
The rapid absorption of blood and blood components forms a reservoir of biologically important cells and cell components to help kick-start the tissue repair process.(1-4) Fibroblast, endothelial and immune cells infiltrate the entire matrix, build new tissue and over time Myriad Matrix™ is completely remodeled by the patient’s own tissue.(3, 4)
Delivers biology known to be important in healing
Myriad Matrix™ retains the authentic structure and complexity of natural tissue ECM and provides biological cues to aid the repair process.(5) Myriad Matrix™ contains more than 150 ECM proteins, including collagen and other secondary molecules that exist in tissue and aid the healing process.(6)
Contains residual vascular channels
Angioconduction is the structural effect of vascular channels on endothelial cells to support blood vessel development. Myriad Matrix™ promotes angioconduction via the residual vascular channels within the Aroa ECM™ source biomaterial, helping to facilitate the rapid establishment of a dense capillary network.(7, 8)
1. G. A. Bohn and A. E. Chaffin: Extracellular matrix graft for reconstruction over exposed structures: a pilot case series. J Wound Care, 29(12), 742-749 (2020) doi:10.12968/jowc.2020.29.12.742 2. A. E. Chaffin and M. C. Buckley: Extracellular matrix graft for the surgical management of Hurley stage III hidradenitis suppurativa: a pilot case series. J Wound Care, 29(11), 624-630 (2020) doi:10.12968/jowc.2020.29.11.624 3. S. M. Irvine, J. Cayzer, E. M. Todd, S. Lun, E. W. Floden, L. Negron, J. N. Fisher, S. G. Dempsey, A. Alexander, M. C. Hill, A. O’Rouke, S. P. Gunningham, C. Knight, P. F. Davis, B. R. Ward and B. C. H. May: Quantification of in vitro and in vivo angiogenesis stimulated by ovine forestomach matrix biomaterial. Biomaterials, 32(27), 6351-61 (2011) doi:l10.1016/j.biomaterials.2011.05.040 4. N. Overbeck, G. M. Nagvajara, S. Ferzoco, B. C. H. May, A. Beierschmitt and S. Qi: In-vivo evaluation of a reinforced ovine biologic: a comparative study to available hernia mesh repair materials. Hernia, 10.1007/s10029-019-02119-z (2020) 5. S. Lun, S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. May: A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 31(16), 4517-29 (2010) doi:10.1016/j.biomaterials.2010.02.025 6. S. G. Dempsey, C. H. Miller, R. C. Hill, K. C. Hansen and B. C. H. May: Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix. J Proteome Res, 18(4), 1657-1668 (2019) doi:10.1021/acs.jproteome.8b00908 7. Smith MJ, Dempsey SG, Veale RW, et al. Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair. Journal of Biomaterials Applications. 2022;36(6):996-1010. doi:10.1177/08853282211045770 8. N. S. Greaves, S. A. Lqbal, J. Morris, B. Benatar, T. Alonso-Rasgado, M. Baguneid and A. Bayat: Acute cutaneous wounds treated with human decellularised dermis show enhanced angiogenesis during healing. PLoS One, 10(1), e0113209 (2015) doi:10.1371/journal.pone.0113209
Myriad Matrix™ is indicated for implantation to reinforce soft tissue where weakness exists in patients requiring soft tissue repair or reinforcement in plastic and reconstructive surgery, or for management of the following wounds:
Aroa Biosurgery is committed to offering a suite of advanced extracellular matrix (ECM) products that not only spans the different sites of care, but also offers the AROA Continuum of Care allowing you to select the product based on your healing objectives and application setting.
This page is dedicated to reimbursement information and support for our products. Should you wish to speak to one of our specialist reimbursement support team, please contact us on:
Should you require additional or more comprehensive information, please find it available on the Centers for Medicare and Medicaid Services website.
Product availability may vary by country, Please check with your local sales representative or distributor for more information.
The information on this page is intended for healthcare professionals only. Not all products or indications are licensed in every country.
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