Clinical Evidence
Endoform® is a proprietary extracellular matrix (ECM) biomaterial containing a rich and complex mix of important biological molecules, including structural (collagens I, III, IV & elastin) and adhesive proteins (fibronectin and laminin), glycosaminoglycans (heparin sulphate and hyaluronic acid) and growth factors (FGF2 & TGFß).
Peer-Reviewed Clinical Studies
Veale, R. W. F., Kollmetz, T., Taghavi, N., Duston-Fursman, C. G., Beeson, M. T., Asefi, D., Chittock, H. D., Vikranth, A. S., Dowling, S. G., Dempsey, S. G., Rose, H. J., Mason, I. T. T., & May, B. C. H. (2022). Influence of advanced wound matrices on observed vacuum pressure during simulated negative pressure wound therapy. J Mech Behav Biomed Mater, 138, 105620.
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Nair, H. K. R., B. A. Bosque and S. G. Dowling (2022). “Use of an advanced extracellular matrix dressing in the treatment of acute and chronic wounds: a Malaysian case series.” Wounds Asia 5(1): 40 – 46.
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Timmer, A. S., J. J. M. Claessen, I. M. Brouwer de Koning, S. M. Haenen, E. J. T. Belt, A. Bastiaansen, E. G. G. Verdaasdonk, C. P. Wolffenbuttel, W. H. Schreurs, W. A. Draaisma and M. A. Boermeester (2022). “Clinical outcomes of open abdominal wall reconstruction with the use of a polypropylene reinforced tissue matrix: a multicenter retrospective study.” Hernia Apr 19.
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Al Mousa, R. H., B. A. Bosque and S. G. Dowling (2022). “Use of ovine forestomach matrix in the treatment of facial thermal burns.” Wounds 34(4): e17-21.
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Sivaraj, D., D. Henn, K. S. Fischer, T. S. Kim, C. K. Black, J. Q. Lin, J. A. Barrera, M. C. Leeolou, N. S. Makarewicz, K. Chen, D. P. Perrault, G. C. Gurtner, G. K. Lee and R. Nazerali (2022). “Reinforced Biologic Mesh Reduces Postoperative Complications Compared to Biologic Mesh after Ventral Hernia Repair.” Plast Reconstr Surg Glob Open 10(2): e4083.
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Sawyer, M., S. Ferzoco and G. DeNoto, 3rd (2021). “A Polymer-Biologic Hybrid Hernia Construct: Review of Data and Early Experiences.” Polymers (Basel) 13(12).
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Ankney, C., C. Banaschak, B. Sowers and P. Szotek (2021). “Minimizing Retained Foreign Body in Hernia Repair Using a Novel Technique: Reinforced Biologic Augmented Repair (ReBAR).” J Clin Med Res 3(4): 1-11.
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DeNoto, G., E. P. Ceppa, S. J. Pacella, M. Sawyer, G. Slayden, M. Takata, G. Tuma and J. Yunis (2021). “A Prospective, Single Arm, Multi-Center Study Evaluating the Clinical Outcomes of Ventral Hernias Treated with OviTex® 1S Permanent Reinforced Tissue Matrix: The BRAVO Study 12-Month Analysis.” J. Clin. Med. 10(21): 4998.
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Bosque, B. A., C. Frampton, A. E. Chaffin, G. A. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2021). “Retrospective real-world comparative effectiveness of ovine forestomach matrix and collagen/ORC in the treatment of diabetic foot ulcers.” Int Wound J 2021 Aug 6 (Epub ahead of print).
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Chaffin, A. E., S. G. Dowling, M. S. Kosyk and B. A. Bosque (2021). “Surgical reconstruction of pilonidal sinus disease with concomitant extracellular matrix graft placement: a case series.” J Wound Care 30(Sup7): S28-S34.
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Boyar, V. (2021). “Association of Systemic or Intravitreal Antivascular Endothelial Growth Factor (Anti-VEGF) and Impaired Wound Healing in Pediatric Patients: Collagen to the Rescue.” J Wound Ostomy Continence Nurs 48(3): 256-261.
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Blevins, M. (2021). “Atypical Ulcerative Necrobiosis Lipoidica Diabeticorum: A Case Study.” Int J Low Extrem Wounds: 1534734621999269.
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Desvigne, M. N., K. Bauer, K. Holifield, K. Day, D. Gilmore and A. L. Wardman (2020). “Case Report: Surgical Closure of Chronic Soft Tissue Defects Using Extracellular Matrix Graft Augmented Tissue Flaps.” Frontiers in Surgery 7(173).
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Chaffin, A. E. and M. C. Buckley (2020). “Extracellular matrix graft for the surgical management of Hurley stage III hidradenitis suppurativa: a pilot case series.” J Wound Care 29(11): 624-630.
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Bohn, G. A. (2020). “Using Ovine Extracellular Matrix in Difficult to Close Excisions of Common Skin Cancer: an Evolving New Technique.” Surg Technol Int 37: 49-53.
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Bohn, G. A. and A. E. Chaffin (2020). “Extracellular matrix graft for reconstruction over exposed structures: a pilot case series.” J Wound Care 29(12): 742-749.
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Raizman R, Hill R, Woo K. Prospective Multicenter Evaluation of an Advanced Extracellular Matrix for Wound Management [published online ahead of print, 2020 May 27]. Adv Skin Wound Care 33(8): 437-444.
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Parker, M. J., R. C. Kim, M. Barrio, J. Socas, L. R. Reed, A. Nakeeb, M. G. House and E. P. Ceppa (2020). “A novel biosynthetic scaffold mesh reinforcement affords the lowest hernia recurrence in the highest-risk patients.” Surg Endosc 35(9): 5173-5178.
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Sawyer, M. A. J. (2018). “New Ovine Polymer-Reinforced Bioscaffold in Hiatal Hernia Repair.” JSLS 22(4).
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Ferzoco, F. J. (2018). “Early experience outcome of a reinforced Bioscaffold in inguinal hernia repair: A case series.” International Journal of Surgery Open 12: 9-11
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Lullove, E. J. (2017). “Use of Ovine-based Collagen Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foam Dressings to Help Improve Clinical Outcomes in Lower Extremity Wounds: A Retrospective Cohort Study.” Wounds 29(4): 107-114.
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Ferreras, D. T., S. Craig and R. Malcomb (2017). “Use of an Ovine Collagen Dressing with Intact Extracellular Matrix to Improve Wound Closure Times and Reduce Expenditures in a US Military Veteran Hospital Outpatient Wound Center.” Surg Technol Int 30: 61-69.
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Gonzalez, A. (2016). “Use of Collagen Extracellular Matrix Dressing for the Treatment of a Recurrent Venous Ulcer in a 52-Year-Old Patient.” J Wound Ostomy Continence Nurs 43(3): 310-312.
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Bohn, G. A. and K. Gass (2014). “Leg ulcer treatment outcomes with new ovine collagen extracellular matrix dressing: a retrospective case series.” Adv Skin Wound Care 27(10): 448-454.
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Simcock, J., & May, B. C. (2013). Ovine forestomach matrix as a substrate for single-stage split-thickness graft reconstruction. Eplasty, 13, e58.
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Simcock, J. W., M. Than, B. R. Ward and B. C. May (2013). “Treatment of ulcerated necrobiosis lipoidica with ovine forestomach matrix.” J Wound Care 22(7): 383-384.
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Simcock, J. and B. C. May (2013). “Ovine forestomach matrix as a substrate for single-stage split-thickness graft reconstruction.” Eplasty 13: e58.
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Liden, B. A. and B. C. May (2013). “Clinical outcomes following the use of ovine forestomach matrix (endoform dermal template) to treat chronic wounds.” Adv Skin Wound Care 26.
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Conference Proceedings
Chaffin, A. E. and M. N. Desvigne (2023). Pressure Injury Reconstruction Utilizing an Ovine Forestomach Matrix Graft. National Pressure Injury Advisory Panel, 17-18 March, 2023. San Diego, California, USA.
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Melin, M., R. Kaufman, J. E. J. Geiger, I. Zilberman, N. Zolfaghari, H. Que, J. Longobardi, J. W. Dutch, J. Skurka, B. A. Bosque, S. G. Dowling and B. C. H. May (2023). Clinical Effectiveness of Ovine Forestomach Matrix Graft in Complex Lower Limb Reconstruction and Limb Salvage. European Wound Management Association, 03-05 May 2023. Milan, Italy.
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Chaffin, A. E. (2023). Pressure Injury Reconstruction Utilizing an Ovine Forestomach Matrix Graft. Symposium on Advanced Wound Care (SAWC), April 26-30, 2023. National Harbor, Maryland, USA.4) Chaffin, A. E. (2023). Pressure Injury Reconstruction Utilizing an Ovine Forestomach Matrix Graft. Symposium on Advanced Wound Care (SAWC), April 26-30, 2023. National Harbor, Maryland, USA.
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Cormican, M. T., N. J. Creel, P. P. Rideout and W. M. Vassy (2023). Ovine Forestomach Matrix in the Surgical Management of Complex Volumetric Soft Tissue Defects: A Retrospective Case Series. Symposium on Advanced Wound Care (SAWC), April 26-30, 2023. National Harbor, Maryland, USA.
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Lawlor, J. C. (2023). Surgical Management of Complex Limb Salvage with Ovine Forestomach Matrix. Symposium on Advanced Wound Care (SAWC), April 26-30, 2023. National Harbor, Maryland, USA.
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Melin, M., R. Kaufman, J. E. J. Geiger, I. Zilberman, N. Zolfaghari, H. Que, J. Longobardi, J. W. Dutch, J. Skurka, B. A. Bosque and S. G. Dowling (2023). Clinical Effectiveness of Ovine Forestomach Matrix Graft in Complex Lower Limb Reconstruction and Limb Salvage. Nurses Specialized in Wound, Ostomy and Continence Canada, May 03-07,2023. Ottawa, Ontario, Canada.
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Blasina, M. (2023). Use of ECM Scaffold Derived From Ovine Forestomach: An Italian Experience in Outpatient and Inpatient Settings. European Wound Management Association, 03-05 May, 2023. Milan, Italy.
Scarpa, C. (2023). The Ovine Extracellular Matrix in Acute and Chronic Wounds: Our Preliminary Experience. European Wound Management Association, 03-05 May, 2023. Milan, Italy.
Bosque, B. A., C. Frampton, A. E. Chaffin, G. A. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2023). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. European Wound Management Association, 03-05 May, 2023. Milan, Italy.
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Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. May (2023). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. Nurses Specialized in Wound, Ostomy and Continence Canada, May 03-07, 2023. Ottawa, Ontario, Canada.
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Desrosiers III, A. (2022). Postsurgical Pyoderma Gangrenosum in Bilateral Breast Reduction Surgery. Innovations in Wound Healing, Dec 04 – 07, 2022. Florida, USA.
Chaffin, A. E., M. Melin and L. Mohan (2022). Novel treatment algorithm of Pyoderma Gangrenosum with Hypochlorous acid and Ovine Forestomach Matrix; Can the dogma of pathergy be altered? Innovations in Wound Healing, Dec 04 – 07, 2022. Florida, USA.
LaLama, A. J. (2022). Ovine Forestomach Matrix in the Surgical Management of Scleroderma Skin Ulcer. Symposium for Advanced Wound Care – Fall, November 2-5, Las Vegas, NV.
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Canfield, A. and R. Kemp (2022). Ovine Forestomach Matrix in the Management of a Complicated Abdominal Surgical Dehiscence. Symposium for Advanced Wound Care – Fall, November 2-5, Las Vegas, NV.
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Chaffin, A. E. (2022). Full Thickness Wound Reconstruction After Wide Excision of Recurrent Plantar Fibromatosis. Symposium for Advanced Wound Care – Fall, November 2-5, Las Vegas, NV.Symposium for Advanced Wound Care – Fall, November 2-5, Las Vegas, NV.
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Taarea, R., J. J. Donahue and C. Castater (2022). Ovine Forestomach Matrix in the Surgical Management of Complex and Contaminated Soft Tissue Trauma. Symposium for Advanced Wound Care – Fall, November 2-5, Las Vegas, NV.
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Howie, Q., J. Longobardi, M. M. Melin, R. Kaufman, J. J. E. Geiger, I. Zilberman, J. W. Dutch, J. Skurka, B. A. Bosque and S. G. Dowling (2022). Clinical Effectiveness of Ovine Forestomach Matrix Graft in Complex Lower Limb Reconstruction and Limb Salvage. Diabetic Global Foot Conference, September 29th-October 1st, Los Angeles, CA.
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Gilleece, D. and A. Sutton (2022). Extracellular matrix technology as an adjunct to prevent limb amputation in the diabetic foot ulcer (DFU) population. NZWCS Conference 2022, 15-17 September Hamilton, New Zealand.
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Morgan, B. (2022). Advanced ECM technology for the treatment of surgical wounds resulting from a recurrent pressure injury. NZWCS Conference 2022, 15-17 September Hamilton, New Zealand.
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Hsu, A. T.-W., K. Schlidt, C. R. D’Adamo, B. A. Bosque, S. G. Dowling and J. H. Wolf (2022). Successful outcomes in anal fistula treatment using ovine forestomach matrix implant technique. ASCRS Annual Scientific Meeting, April 30 – May 4, Tampa, FL.
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Kokal, W. and P. Price (2022). A Case Report of the Treatment of Pemphigus Vulgaris Utilizing an Extracellular Matrix Graft (Oral Presentation). John A. Boswick Burn and Wound Care Symposium January 21-26, 2022, Wailea Beach Resort – Marriott – Wailea – Maui, Hawaii.
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Melin, M. (2022). Clinical Effectiveness of Ovine Forestomach Matrix Graft in Complex Lower Limb Reconstruction and Limb Salvage (Oral Presentation). John A. Boswick Burn and Wound Care Symposium January 21-26, 2022, Wailea Beach Resort – Marriott – Wailea – Maui, Hawaii.
Chaffin, A. E. (2022). Morselized Extracellular Matrix Graft to Improve Split Thickness Skin Graft Outcomes: A Retrospective Case Series (Oral Presentation). John A. Boswick Burn and Wound Care Symposium January 21-26, 2022, Wailea Beach Resort – Marriott – Wailea – Maui, Hawaii.
Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2022). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. World Union of Wound Healing Societies, 1-5 March 2022, Abu Dhabi.
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Al Mousa, R. H., B. A. Bosque and S. G. Dowling (2022). A Case Report: Utilizing Ovine Forestomach Matrix in the Subacute Treatment of Fascial Thermal Burn. World Union of Wound Healing Societies, 1-5 March 2022, Abu Dhabi.
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Chaffin, A. E. (2022). A surgical technique for flap reconstruction of pilonidal sinus using extracellular matrix graft (oral presentation). World Union of Wound Healing Societies, 1-5 March 2022, Abu Dhabi.
Melin, M., R. Kaufman, J. E. J. Geiger and B. A. Bosque (2022). Ovine Forestomach Matrix in the Surgical Management of Complex Lower Extremity Soft Tissue Defects : A Retrospective Multi-Center Case Series. American Professional Wound Care Association, Wound Week, 2022 (February 24-27, 2022) Loews Philadelphia Hotel, Philadelphia, PA.
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Geiger, J. E. J., R. Kaufman, I. Zilberman, N. Zolfaghari, W. Dutch and B. A. Bosque (2022). Continuity of Care: Retrospective Review of Ovine Forestomach Matrix Efficacy Across All Phases of Wound Healing. Symposium on Advanced Wound Care – Spring 2022, April 6-10, 2022, Phoenix, AZ.
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Chaffin, A. E., J. Christopher and B. Salah (2022). A retrospective review of soft tissue reconstruction in volumetric soft tissue defects. Symposium on Advanced Wound Care – Spring 2022, April 6-10, 2022 Phoenix, AZ.
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Register, A. (2022). A retrospective review of an extracellular matrix used to treat complex chronic wounds. Symposium on Advanced Wound Care – Spring 2022, April 6-10, 2022, Phoenix, AZ.
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Melin, M. M., R. Kaufman, J. E. J. Geiger, I. Zilberman, N. Zolfaghari, H. Que, J. Longoardi, W. Dutch, J. Skurka, B. A. Bosque and S. G. Dowling (2022). Clinical Effectiveness of Ovine Forestomach Matrix Graft in Complex Lower Limb Reconstruction and Limb Salvage. Symposium on Advanced Wound Care – Spring, April 6-10, 2022, Phoenix, AZ.
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Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2022). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. American Professional Wound Care Association, Wound Week, 2022 (Feburary 24-27, 2022), Loews Philadelphia Hotel, Philadelphia, PA.
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Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2022). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. John A. Boswick Burn and Wound Care Symposium January 21-26, 2022, Wailea Beach Resort – Marriott – Wailea – Maui, Hawaii.
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Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2021). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. Symposium on Advanced Wound Care – Fall, 2021 (October 29-31, 2021), Las Vegas, NV.
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Chaffin, A. E. and J. Christopher (2021). A retrospective review of the early experience with a morselized extracellular matrix. Symposium on Advanced Wound Care – Fall, 2021 (October 29-31), Las Vegas, NV.
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Holloway, B. (2021). Minimally Invasive Closure for Recurrent Pilonidal Sinus Using Extracellular Matrix Graft: A Case Report. Symposium on Advanced Wound Care – Fall, 2021 (October 29-31), Las Vegas, NV.
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Bosque, B. A., C. Frampton, A. E. Chaffin, G. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. Melin, T. Madu, S. G. Dowling and B. C. H. May (2021). Retrospective Real World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen/Oxidized Regenerated Cellulose in the Management of Diabetic Foot Ulcers. DFCon – Diabetic Global Foot Conference, October 21 – 23, 2021. San Franciso, California.
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Geiger, A. J., B. A. Bosque and R. Kaufman (2021). Clinical Effectiveness of Ovine Forestomach Matrix for Coverage of Exposed Vital Structures in Complex Diabetic Foot Ulcer Reconstructions. DFCon – Diabetic Global Foot Conference, October 21 – 23, 2021. San Francisco, California.
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Chaffin, A. E. (2021). Flap Reconstruction of Pilonidal Sinus Using Extracellular Matrix Graft: A Pilot Case Series. Symposium on Advanced Wound Care (SAWC) – Spring, Virtual.
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Chaffin, A. E. (2021). A Surgical Technique for Flap Reconstruction of Pilonidal Sinus Using Extracellular Matrix Graft (Oral Presentation). 44th Annual John A. Boswick Burn & Wound Symposium, Maui, HI.
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Duong, C. H. and J. McGuire (2020). Combination therapy of an bioresorbable synthetic polymer matrix and an ovine collagen dressing for treatment of a recurrent venous leg ulcer: A case study. Symposium on Advanced Wound Care – Fall, 2020 (Nov 4-6), Las Vegas, NV.
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Wahab, N., Lapucha, M., and C. Chauhan (2020). Ovine Forestomach Matrix is Efficacious in the Closure of Significant Post Surgical Undermining. Symposium on Advanced Wound Care – Spring, Virtual Conference.
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Chaffin, A. E., and M. Buckley (2020). Clinical Evaluation of an Extracellular Matrix Graft for the Surgical Management of Hurley Grade III Hidradenitis Suppurativa. Symposium of Advanced Wound Care, Virtual Conference.
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Chaffin, A. E. and M.-C. Buckley (2020). Surgical Management of Hurley Stage III Hidradenitis Suppurativa Using ECM Graft. Symposium on Hidradenitis Suppurativa Advances, 5th Annual SHSA, October 9-11 2020, Virtual.
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Geiger, J. E. J. and J. Skwarczyk (2020). Extracellular matrix-based regeneration over exposed bone and tendon: A prospective case series. DFCon 20 Conference, Oct 9-10 2020, Virtual.
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Chaffin, A. E. (2020). Pilonidal Cystectomy Using Extracellular Matrix Graft. Symposium on Advanced Wound Care – Fall, November 4-6 2020, Virtual.
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Melin, M. and C. Zeleya (2020). Chronic wound management with the innovative ovine extracellular matrix technology: a Honduran experience. Symposium on Advanced Wound Care – Spring 2020 Virtual.
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Hill, R. and K. Woo (2020). Utilization of advanced antimicrobial extracellular matrix technology within the framework of antimicrobial stewardship. Symposium on Advanced Wound Care – Spring 2020 Virtual.
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Chaffin, A. E., A. M. Aballay, G. A. Bohn, P. M. Glat, M. N. Desvigne and B. C. H. May (2019). Multi-Centre Clinical Evaluation of a Cell Conductive Extracellular Matrix Surgical Mesh in Plastics and Reconstructive Surgery – A Case Series. 41st Annual Boswick Burn & Wound Symposium, Wailea Beach, Maui, HI.
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Chaffin, A. E., A. M. Aballay, G. A. Bohn, P. M. Glat, M. N. Desvigne and B. C. May (2019). Multi-Centre Clinical Evaluation of a Cell Conductive Extracellular Matrix Surgical Mesh in Plastics and Reconstructive Surgery – A Case Series. SESPRS 62nd Annual Scientific Meeting, Naples, Florida.
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Ferreras, D. T. and R. L. Crump (2019). Use of a High-Density ECM for the Management of Deep Diabetic Foot Ulcers: A Case Series. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.
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Chaffin, A. E. and G. Bohn (2019). Clinical Evaluation of an Extracellular Matrix Surgical Graft for Reconstructive Surgery over Exposed Bone or Tendon. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.
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Casilang, R., E. Hicks and S. Morrisette (2019). Early Clinical Experience Using an ECM Scaffold with Ionic Silver in Diabetic Patients with Lower Extremity Ulcers. 41st Annual Boswick Burn & Wound Symposium, Wailea Beach, Maui, HI.
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Raizman, R., R. Hill and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. Wounds Canada – Spring, Halifax, NS, Canada.
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Hill, R., R. Raizman and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. NSWOCC 38th National Conference, Lac-Leamy, Ottawa, Canada.
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Stillerman, J. and D. M. Freeman (2019). Using Advanced and Adaptive Technologies for the Management of Wounds – Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foam Dressing. Symposium for Advanced Wound Care – Spring, San Antonio, TX.
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Zilberman, I. and N. Zolfaghari (2019). The Management of Wounds with Exposed Tendon and Bone using Innovative and Complementary Technologies: Ovine Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foams. Symposium on Advanced Wound Care – Spring, San Antonio, TX.
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Morrisette, S., R. Casilang and G. Bohn (2019). Extracellular Matrix Technology for Assessing Wound Protease Concentrations Symposium of Advanced Wound Care – Spring, San Antonio, Tx.
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Zilberman, I. and N. Zolfaghari (2019). The management of wounds with exposed tendon and bone with innovative and complementary technologies: ovine extracellular matrix and gentian violet/methylene blue antibacterial foams. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.
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Woo, K., R. Raizman and R. Hill (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.
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Hill, R., R. Raizman and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. Wounds Canada – Fall, Niagara Falls, Ontario, Canada.
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Hill, R., R. Raizman and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. European Pressure Ulcer Advisory Panel & Société Française de l’Escarre Joint Annual Meeting 2019, Lyon, France
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Zilberman, I. and N. Zolfaghari (2018). Innovative Solutions Utilizing Ovine Extracellular Matrix with Antimicrobial Silver in the Management of Wounds with Exposed Tendon and Bone. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.
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Stillerman, J. (2018). To Preserve and Protect: a Dual Approach to Wound Management using an Extracellular Matrix with Ionic Silver Symposium for Advanced Wound Care – Fall, Las Vegas, NV.
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Casilang, R., E. Hicks and S. Morrisette (2018). Early Clinical Experience Using an ECM Scaffold with Ionic Silver in Diabetic Patients with Lower Extremity Ulcers. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.
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Stillerman, J. (2018). Case Series Using Ovine Extracellular Matrix for the Correction of Stalled Wounds Symposium for Advanced Wound Care – Fall, Las Vegas, NV.
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Silverman, A. and G. Valentine (2018). Use of Ovine Extracellular Matrix in Post-Surgical Wounds: A Case Series. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.
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Morrisette, S., E. Hicks and R. Casilang (2018). Achieving Improved Wound Healing Time and Costs Savings in the Outpatient Wound Care Setting by Utilizing an Extracellular Matrix. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.
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Andersen, C., D. Green, J. Santucci and E. Phillips (2018). Improved Venous Leg Ulcer Outcomes Using a Combination of Ovine Extracellular Matrix and Gentian Violet/Methylene Blue Transfer Antibacterial Foam. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.
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Tickner, A., C. Klinghard and K. Lussier (2018). The Use of Ovine Collagen Extracellular Matrix Dressing in the Effective Treatment of Wounds for Fast Closure and Treatment of Nerve Pain. Symposium on Advanced Wound Care – Spring, Charlotte, NC.
Gatan Mendoza, J., J. Landi and R. Rock (2018). The concurrent Use of Ovine Collagen Extracellular Matrix Dressing with Negatvie Pressure Wound Therapy on Three Acute Surgical Wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC.
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Mier, Y. (2018). Case Series of using collagen dressing in stalled wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC.
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Lindberg, G. and M. Diss (2018). Complete Wound Closure in Partial Thickness Burns with the Use of Collagen Extracellular Matrix Dressings and Antibacterial Foams. Symposium on Advanced Wound Care – Spring, Charlotte, NC.
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Jerome, D. and J. Clancy (2018). Incorporating advanced wound care to help restore skin health in three patients with peristomal skin complications. Wound Ostomy and Continence Nurse Conference, St. Louis, MO.
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Fleck, K. A., T. Reyes and H. C. Wishall (2018). Effect of Ovine-Based Collagen Extracellular Matrix Dressings on Outcomes in an Outpatient Wound Care Center. Symposium on Advanced Wound Care – Spring, Charlotte, NC.
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Aballay, A. and E. Tolchin (2018). Results of an ovine extracellular matrix dressing in the management of a variety of burns and wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC.
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Silverman, A. (2017). Use of an Ovine Collagen with an Intact Extracellular Matrix (CECM) and negative pressure wound therapy (NPWT) as part of the wound management plan following limb salvage surgical intervention in high risk diabetic foot ulcers. Symposium on Advanced Wound Care – Spring, San Diego, CA.
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McIlrath, P. and J. T. Wattlers (2017). The Use of Ovine Collagen Extracellular Matrix and Gentian Violet and Methylene Blue Antibacterial Foam Dressings in the Effective Treatment of Wounds with Exposed Tendon and Bone in the High Risk Diabetic Foot. Society for Advanced Wound Care – Spring, San Diego, CA.
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Zilberman, I. and N. Zolfaghari (2016). Innovative solutions in the management of wounds with exposed tendons utilizing ovine collagen extracellular matrix and gentian violet and methylene blue antibacterial foams. Symposium for Advanced Wound Care – Spring, Atlanta, GA.
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Vidovic, G. and P. Sykes (2016). The use of an ovine collagen extracellular matrix dressing in conjunction with negative pressure wound therapy in the management of chronic diabetic foot ulcers. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.
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Roith, J. (2016). Managing Diabetic Foot Ulcers Using a Three Pronged Approach: V.I.P. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.
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Petrocelli, M. (2016). Managing Difficult Wounds Secondary to Charcot Deformity with a Novel Total Contact Cast System. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.
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Petrocelli, M. Ostler, M. Liden, B. (2016). Edema reduction with a Novel Total Contact Cast System containing a Mild Compression Sock. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.
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Gonzalez, A. (2016). Use of Collagen Extracellular Matrix Dressing for the Treatment of a Recurrent Venous Ulcer in a 52-Year-Old Patient. Symposium on Advanced Wound Care – Spring, Atlanta, GA.
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Ferreras, D. T., S. Craig and R. Malcomb (2016). Utilization of an ovine collagen dressing with an intact extracellular matrix (CECM) within a dual-protocol algorithm to improve wound closure times and reduce expenditures in a VA Hospital. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.
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Edwards, K., White S. (2016). Use of gentian violet and methylene blue antibacterial foam dressings on various wound types in the acute care setting. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.
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Desvigne, M. N. (2016). Preparing a wound bed before application of cellular tissue based products using an Ovine collagen (CECM) dressing with an intact extracellular matrix. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.
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Bohn, G. and S. Champion (2016). Improved Healing of Stage 3 Pressure Ulcers Using Extracellular Matrix Collagen Dressing. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.
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Weir, D., D. Tedesco and G. Schultz (2015). Enhanced Clinical Effects of Combining Recombinant PDGF with Collagen Dressings in Difficult to Heal Chronic Wounds. Symposium for Advanced Wound Care – Spring, New Orleans, LA.
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Roith, J. and T. Neill (2015). Treating Diabetic Foot Ulcer Patients with an Ovine Collagen Extra Cellular Matrix Prior to cellular Tissue Products. Annual High Risk Diabetic Foot Conference, Phoenix, AZ.
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Pierce, B., J. Galitz, L. Hayes and M. Regan (2015). Wound Management and Estimated Cost Associated with Dermal Templates Containing 10% Extracellular Matrix Components and 90% Intact Collagen. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.
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McGuire, J., N. Mahmudova and W. Lee (2015). Using becaplermin and ovine dermal template (ODT) dressing to heal chronic diabetic foot ulcers. A case series. American Podiatric Medical Association 2015 Annual Scientific Meeting (The National), Orlando, FL.
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Desvigne, M. N. (2015). Ovine collagen extracellular matrix (CECM) Dressing Assisted Closure: For the Acute Wound, Following Mohs Surgical Excision. Clinical Symposium on Advances in Skin & Wound Care. New Orleans, LA.
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Champion, S. and G. Bohn (2015). Dressing Appearance at Change Can Give Insight into Dressing Effectiveness in the Wound. Symposium on Advances in Skin & Wound Care – Spring, New Orleans, LA.
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Zilberman, I. and N. Zolfaghari (2014). Use of ovine collagen extracellular matrix (CECM) dressing and gentian violet and methylene blue (GV/MB) antimicrobial foam dressing in the management of diabetic foot ulcers. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.
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Lullove (2014). Pilot series of recalcitrant lower extremity wounds managed with an ovine collagen extracellular matrix (CECM) and gentian violet/methylene blue (GV/MB) antibacterial foam dressings. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.
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Blaszcyk, J. and A. McIntosh (2014). The effectiveness of an ovine collagen extracellular matrix dressing for chronic non-healing wounds. Symposium on Advanced Wound Care – Spring, Denver, CO.
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Wright, K., D. Hastings, W. Dukes and K. Gorgui (2013). Innovative Dressing Option: Use of a collagen dermal template with extracellular matrix (ECM)* in the management of lower extremity wounds. Clinical Symposium on Advances in Skin & Wound Care, Orlando, FL.
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Pompeo, M., K. Neeley and L. Garner (2013). Utilizing a collagen dermal template in various wound etiologies yielded positive results in an outpatient wound care center. Symposium on Advanced Wound Care – Spring, Denver, CO.
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Miller, S. D., K. Trotter, B. Hong, R. Lenz, D. Nagesh, H. K. Park and M. Garoufalis (2013). An Approach to Treating Neuropathic Pedal Ulcerations with Ovine Collagen Extracellular Matrix (CECM). Symposium on Advanced Wound Care – Spring, Denver, CO.
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Lullove, E. (2013). Use of a collagen dermal template with extracellular matrix (ECM) to treat complex lower extremity wounds. Clinical Symposium on Advances in Skin & Wound Care, Orlando, FL.
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Curran, M., C. Rodriquez, O. J. Altschul, A. Fragen and F. Ercoll (2013). The Use of collagen dermal template with an ECM in various wounds in acute care and outpatient wound care settings. Symposium on Advanced Wound Care – Spring, Denver, CO
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Liden, B., B. R. Ward and B. C. H. May (2011). Early Clinical Findings from the Use of Ovine Forestomach Matrix to Treat Recalcirant Wounds. Symposium on Advanced Wound Care – Spring, Dallas, Tx.
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Clinical Consensus Papers
Bohn, G. A. (2019). “Endoform: A Simple Tool to Assess Wound Proteases.” Wound Management and Prevention 65(3): 18-20.
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Casilang, R. and S. Morrisette (2019). “Utilizing Endoform as a Surrogate Marker of Wound Protease Levels in Chronic Wounds.” Wound Management and Prevention 65(5): 8-10.
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S. Morrisette (2019). “Using Endoform as a Protease Indicator to Standardize Wound Management.” Wound Management and Prevention 65(8): 8-10.
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Bohn, G. (2019). “Complex Problem, Simple Solution: Using Endoform to Provide a Functional Extracellular Matrix in Chronic Wounds.” Wound Management and Prevention 65(10): 8-10.
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Boyar, V. (2019). “Collagen: providing a key to the wound healing kingdom.” Wound Management and Prevention 65(8): 12-14.
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Zilberman, I. and N. Zolfaghari (2018). “Adding an Antimicrobial With Silver to Your Wound Care Armamentarium.” Ostomy and Wound Management August 2018: 10-11.
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Zilberman, I. and N. Zolfaghari (2018). “Taking the Guess Work Out of Silver Use.” Ostomy and Wound Management October 2018: 12-14.
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Gonzalez, A. (2018). “Managing Pressure Injuries in Home Health Care.” Ostomy and Wound Management 64(4): 12-14.
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Edwards, K. (2018). “Collaborating with WOC Nurses to Optimize Patient Progress.” Ostomy and Wound Management May 2018: 10-12.
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Ferreras, D. T. (2017). “Wound Bed Preparation: Is It Time to Up Your Game?” Ostomy and Wound Management 63(12): 10-11.
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Bohn, G. A., G. S. Schultz, B. A. Liden, M. N. Desvigne, E. J. Lullove, I. Zilberman, M. B. Regan, M. Ostler, K. Edwards, G. M. Arvanitis and J. F. Hartman (2017). “Proactive and Early Aggressive Wound Management: A Shift in Strategy Developed by a Consensus Panel Examining the Current Science, Prevention, and Management of Acute and Chronic Wounds.” Wounds 29(11): S37-S42.
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Bohn, G., B. Liden, G. Schultz, Q. Yang and D. J. Gibson (2016). “Ovine-Based Collagen Matrix Dressing: Next-Generation Collagen Dressing for Wound Care.” Adv Wound Care (New Rochelle) 5(1): 1-10.
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Sibbald, R. G., L. G. Ovington, E. A. Ayello, L. Goodman and J. A. Elliott (2014). “Wound bed preparation 2014 update: management of critical colonization with a gentian violet and methylene blue absorbent antibacterial dressing and elevated levels of matrix metalloproteases with an ovine collagen extracellular matrix dressing.” Adv Skin Wound Care 27(3 Suppl 1): 1-6.
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Pre-Clinical Literature
Dowling, S. G. and R. W. Veale (2022). Influence of Advanced Wound Matrices on Observed Vacuum Pressures During Simulated Negative Pressure Wound Therapy. Innovations in Wound Healing, Dec 04 – 07, 2022 Islamorada, Florida, USA.
Overbeck, N., A. Beierschmitt, B. C. H. May, S. Qi and J. Koch (2022). “In-Vivo Evaluation of a Reinforced Ovine Biologic for Plastic and Reconstructive Procedures in a Non-human Primate Model of Soft Tissue Repair.” ePlasty 22(e43).
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Smith, M. J., S. G. Dempsey, R. W. Veale, C. G. Duston-Fursman, C. A. F. Rayner, C. Javanapong, D. Gerneke, S. G. Dowling, B. A. Bosque, T. Karnik, M. J. Jerram, A. Nagarajan, R. Rajam, A. Jowsey, S. Cutajar, I. Mason, R. G. Stanley, A. Campbell, J. Malmstrom, C. H. Miller and B. C. H. May (2021). “Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair.” J Biomater Appl: 8853282211045770.
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Dempsey, S. G., C. H. Miller, J. Schueler, R. W. F. Veale, D. J. Day and B. C. H. May (2020). “A novel chemotactic factor derived from the extracellular matrix protein decorin recruits mesenchymal stromal cells in vitro and in vivo.” PLoS One 15(7): e0235784.
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Overbeck, N., G. M. Nagvajara, S. Ferzoco, B. C. H. May, A. Beierschmitt and S. Qi (2020). “In-vivo evaluation of a reinforced ovine biologic: a comparative study to available hernia mesh repair materials.” Hernia.
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Karnik, T., S. G. Dempsey, M. J. Jerram, A. Nagarajan, R. Rajam, B. C. H. May and C. H. Miller (2019). “Ionic silver functionalized ovine forestomach matrix – a non-cytotoxic antimicrobial biomaterial for tissue regeneration applications.” Biomater Res 23: 6
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Dempsey, S. G., C. H. Miller, R. C. Hill, K. C. Hansen and B. C. H. May (2019). “Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix.” J Proteome Res 18(4): 1657-1668.
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Frost, S. J., D. Mawad, R. Wuhrer, S. Myers and A. Lauto (2018). “Semitransparent bandages based on chitosan and extracellular matrix for photochemical tissue bonding.” Biomed Eng Online 17(1): 7.
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Dempsey, S. G., S. Cutajar, A. Nagarajan, R. Rajam, M. J. Jerram, T. Karnik, C. H. Miller and B. C. H. May (2018). Structural Diversity of Decellularized Ovine Forestomach Matrix. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.
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Karnik, T., M. J. Jerram, A. Nagarajan, R. Rajam, S. G. Dempsey, B. C. May and C. H. Miller (2018). Antimicrobial Functionalization of Ovine Forestomach Matrix With Ionic Silver. Symposium on Advanced Wound Care – Spring, Charlotte, NC.
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Jerram, M. J., T. Karnik, A. Nagarajan, R. Rajam, S. G. Dempsey, B. C. May and C. H. Miller (2018). Antimicrobial Ovine Forestomach Matrix Prevents Biofilm Formation. Symposium on Advanced Wound Care – Spring, Charlotte, NC.
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Sizeland, K. H., H. C. Wells, S. J. R. Kelly, K. E. Nesdale, B. C. H. May, S. G. Dempsey, C. H. Miller, N. Kirby, A. Hawley, S. Mudie, T. Ryan, D. Cookson and R. G. Haverkamp (2017). “Collagen Fibril Response to Strain in Scaffolds from Ovine Forestomach for Tissue Engineering.” ACS Biomater. Sci. Eng. 3(10): 2550–2558.
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Street, M., A. Thambyah, M. Dray, S. Amirapu, D. Tuari, K. E. Callon, J. D. McIntosh, K. Burkert, P. R. Dunbar, B. Coleman, J. Cornish and D. S. Musson (2015). “Augmentation with an ovine forestomach matrix scaffold improves histological outcomes of rotator cuff repair in a rat model.” J Orthop Surg Res 10: 165.
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Negron, L., S. Lun and B. C. H. May (2014). “Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase.” Int Wound J 11(4): 392-397.
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Merrilees, M. J., B. A. Falk, N. Zuo, M. E. Dickinson, B. C. H. May and T. N. Wight (2014). “Use of versican variant V3 and versican antisense expression to engineer cultured human skin containing increased content of insoluble elastin.” J Tissue Eng Regen Med 11(1): 295-305.
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Irvine, S. M., J. Cayzer, E. M. Todd, S. Lun, E. W. Floden, L. Negron, J. N. Fisher, S. G. Dempsey, A. Alexander, M. C. Hill, A. O’Rouke, S. P. Cunningham, C. Knight, P. F. Davis, B. R. Ward and B. C. H. May (2011). “Quantification of in vitro and in vivo angiogenesis stimulated by ovine forestomach matrix biomaterial.” Biomaterials 32(27): 6351-6361.
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Irvine, S. M., J. Cayzer, E. M. Todd, S. Lun, E. W. Floden, L. Negron, S. G. Dempsey, A. Alexander, S. P. Gunningham, C. Knight, P. F. Davis, B. R. Ward and B. C. H. May (2011). Ovine Forestomach Matrix (OFM) Stimulates Angiogenesis In Vitro and In Vivo. Symposium on Advanced Wound Care – Spring, Dallas, TX.
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Floden, E. W., S. F. F. Malak, M. M. Basil-Jones, L. Negron, J. N. Fisher, S. Lun, S. G. Dempsey, R. G. Haverkamp, B. R. Ward and B. C. H. May (2011). Biophysical Characterisation of Ovine Forestomach Extracellular Matrix Biomaterials. Australasian Society for Biomaterials and Tissue Engineering, Queenstown, New Zealand.
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Floden, E. W., S. F. Malak, M. M. Basil-Jones, L. Negron, J. N. Fisher, S. Lun, S. G. Dempsey, R. G. Haverkamp, B. R. Ward and B. C. May (2010). “Biophysical characterization of ovine forestomach extracellular matrix biomaterials.” J Biomed Mater Res B Appl Biomater 96(1): 67-75.
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Lun, S., S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. H. May (2010). “A functional extracellular matrix biomaterial derived from ovine forestomach.” Biomaterials 31(16): 4517-4529.
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May, B. C. H., S. M. Irvine, S. Lun, E. W. Floden and B. R. Ward (2010). Ovine Forestomach Matrix (EndoformTM) Stimulates Cell Differentiation and Vascularisation. Symposium on Advanced Wound Care – Spring, Orlando, FL.
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May, B. C. H., S. Lun, J. N. Fisher, E. W. Floden and B. R. Ward (2009). Endoform™ Dermal Template – Authentic Complexity. Symposium on Advanced Wound Care – Spring, Dallas, Tx.
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